2-Amino-5-(trifluoromethoxy)benzoic acid CAS 83265-56-9
| CAS No. | 83265-56-9 |
| Molecular Formula | C8H6F3NO3 |
| Molecular Weight | 221.13 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2-Amino-5-(trifluoromethoxy)benzoic acid (CAS 83265-56-9) is a high-purity analytical reference standard with the molecular formula C8H6F3NO3 and a molecular weight of 221.13 g/mol.
2-Amino-5-(trifluoromethoxy)benzoic acid (C8H6F3NO3) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H6F3NO3 |
| Molecular Weight | 221.13 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1980 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Amino Standards
- 3-Amino-5-(trifluoromethoxy)benzoic acid (CAS 1163141-31-8)
- 2-Amino-4-(trifluoromethoxy)benzoic acid (CAS 1259323-62-0)
- 4-Amino-3-(trifluoromethoxy)benzoic Acid (CAS 175278-22-5)
- 2-Amino-3-(trifluoromethoxy)benzoic Acid (CAS 561304-41-4)
- 2-Amino-6-(trifluoromethoxy)benzoic acid (CAS 561304-48-1)
- 2-Amino-6-hydroxy-4-(trifluoromethyl)benzoic acid (CAS 315-15-1)
- 3-Amino-4-(trifluoromethoxy)benzoic acid (CAS 656-06-4)
- 5-Amino-2-(trifluoromethoxy)benzoic acid (CAS 307989-56-6)
Recommended Standards
- 2-[2-oxo-3-(trifluoromethyl)-1,2-dihydropyridin-1-yl]acetic acid (CAS 950114-48-4)
- 2-(2-Oxo-5-(trifluoromethyl)pyridin-1(2H)-yl)acetic acid (CAS 308294-33-9)
- 2-Hydroxy-4-methyl-5-nitrobenzotrifluoride (CAS 1987007-14-6)
- 2-(2,3-Difluoro-4-(trifluoromethyl)phenyl)acetonitrile (CAS 240800-44-6)
- 1-(5-Bromo-2,3-difluorophenyl)-4-ethylpiperazine (CAS 1704067-20-8)
- 7-Bromoacetyl-3,4-dihydro-1,5-benzodioxepin (CAS 35970-34-4)
- N-(2-Hydroxyethyl)pentadecanamide (CAS 53832-58-9)
- 2-Amino-N-ethyl-2-thioxoacetamide (CAS 54699-19-3)
- ((2,3-Dichlorophenyl)sulfonyl)-l-tryptophan (CAS 1212102-52-7)
- 2,4-Dihydroxy-5,6-dimethyl Nicotinic Acid Ethyl Ester (CAS 77629-51-7)
- 4-(4-Chlorophenyl)-1,2,3-thiadiazol-5-amine hydrochloride (CAS 1185292-71-0)
- 1-(Benzoylamino)cyclohexanecarboxylic acid (CAS 107521-99-3)
- (4-Amino-3-chloro-5-(trifluoromethyl)phenyl)methanol (CAS 600725-44-8)
- Semaglutide Impurity 188 (CAS CATO-C4X-2226188)
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