1-[4-methyl-6-(trifluoromethyl)pyrimidin-2-yl]piperidine-4-carboxylic acid CAS 832737-40-3
| CAS No. | 832737-40-3 |
| Molecular Formula | C12H14F3N3O2 |
| Molecular Weight | 289.25 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 1-[4-methyl-6-(trifluoromethyl)pyrimidin-2-yl]piperidine-4-carboxylic acid is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies 1-[4-methyl-6-(trifluoromethyl)pyrimidin-2-yl]piperidine-4-carboxylic acid (CAS 832737-40-3), a certified reference material (molecular formula C12H14F3N3O2, MW 289.25 g/mol) for analytical method development and quality control.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, 1-[4-methyl-6-(trifluoromethyl)pyrimidin-2-yl]piperidine-4-carboxylic acid is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 289.25 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 1-[4-methyl-6-(trifluoromethyl)pyrimidin-2-yl]piperidine-4-carboxylic acid under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C12H14F3N3O2 |
| Molecular Weight | 289.25 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related methyl Standards
- 1-[2-Methyl-6-(trifluoromethyl)pyrimidin-4-yl]piperidine-4-carboxylic acid (CAS 1574546-15-8)
- 1-(2-Methyl-6-(trifluoromethyl)pyrimidin-4-yl)piperidine-3-carboxylic acid (CAS 1708268-55-6)
- (E)-2-(3-(trifluoromethyl)styryl)benzo[d]oxazole (CAS 388090-63-9)
- 1-[4-methyl-6-(trifluoromethyl)pyrimidin-2-yl]piperidine-3-carboxylic acid (CAS 861451-76-5)
- 1-Phenyl-2-(trifluoromethyl)quinolin-4(1H)-one (CAS 837364-35-9)
- 2-(2-Oxo-2-(2-(trifluoromethyl)phenyl)ethyl)benzonitrile (CAS 898784-45-7)
- 2-Phenyl-7-(trifluoromethyl)quinolin-4-ol (CAS 825620-20-0)
- 4-((Trifluoromethyl)sulfonyl)benzenesulfonamide (CAS 2070-48-6)
Recommended Standards
- 1-[2-Nitro-4-(trifluoromethyl)phenyl]-1,4-diazepane (CAS 646455-48-3)
- 2-(2-Cyanophenyl)-3-trifluoromethylacetophenone (CAS 898784-47-9)
- 2-(2-Cyanophenyl)-4-trifluoromethylacetophenone (CAS 898784-49-1)
- (3Z)-1,1,1-Trifluoro-4-[(2-hydroxyethyl)amino]-4-(2-hydroxy-5-methylphenyl)-3-buten-2-one (CAS 781652-21-9)
- 3-(Perfluoroethoxy)aniline (CAS 717-84-0)
- 4,6-Dimethoxybenzo[d][1,3]dioxole-5-carboxylic acid (CAS 68803-44-1)
- 2-Bromo-4-(1,1,1,3,3,3-hexafluoropropan-2-yloxy)-1-(trifluoromethyl)benzene (CAS 1779132-37-4)
- 6-(3-Methoxyphenyl)imidazo[2,1-b]thiazole-5-carbaldehyde (CAS 439094-67-4)
- 1,4-Bis(4-methylfuran-2-yl)cyclohexane (CAS 68769-11-9)
- n-(3-Ethoxypropyl)-3,3-dimethylcyclohexan-1-amine (CAS 1340486-57-8)
- Asp(Obzl)-NCA (CAS 13590-42-6)
- 3-Amino-1-[(4-methoxyphenyl)methyl]thiourea (CAS 16735-76-5)
- Methyl (5-oxo-4,5,6,7-tetrahydropyrazolo-[1,5-a]pyrimidin-6-yl)acetate (CAS 1049118-96-8)
- ([13C6]Leu14)-Glucagon (1-29) (human, rat, porcine) trifluoroacetate salt (CAS 1802078-39-2)
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