8-Bromo-3-fluoroquinoline-4-carboxylic acid CAS 834884-22-9
| CAS No. | 834884-22-9 |
| Molecular Formula | C10H5BrFNO2 |
| Molecular Weight | 270.05 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
8-Bromo-3-fluoroquinoline-4-carboxylic acid (CAS 834884-22-9) is a high-purity analytical reference standard with the molecular formula C10H5BrFNO2 and a molecular weight of 270.05 g/mol.
The molecular framework of 8-Bromo-3-fluoroquinoline-4-carboxylic acid (C10H5BrFNO2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/bromine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), 8-Bromo-3-fluoroquinoline-4-carboxylic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H5BrFNO2 |
| Molecular Weight | 270.05 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Halogen Content | F/Br-containing |
| Nitrogen Atoms | 1 |
Related Bromo Standards
- 5-Bromo-2-(2,2,2-trifluoroethoxy)aniline (CAS 1019121-52-8)
- 8-Bromo-5-fluoroquinoline-2-carboxylic acid (CAS 1067914-57-1)
- (3-Bromo-5-(trifluoromethoxy)phenyl)methanamine (CAS 1092461-37-4)
- (2E)-3-(4-Bromo-2-fluorophenyl)-2-cyanoprop-2-enoic acid 1099670-06-0 C10H5BrFNO2 Z7297 (CAS 1099670-06-0)
- (5-Bromo-2-(trifluoromethoxy)phenyl)methanamine (CAS 1152088-62-4)
- 1-Bromo-3-(trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine (CAS 1152440-29-3)
- 3-Bromo-2-(2,2-difluoroethoxy)-5-fluoroaniline (CAS 1178770-78-9)
- 5-Bromo-3-methyl-2-(2,2,2-trifluoro-ethoxy)-pyridine (CAS 1187930-58-0)
Recommended Standards
- 5-Bromo-2-ethoxy-3-(trifluoromethyl)pyridine (CAS 849934-83-4)
- Crisaborole Impurity 16 (CAS 906673-43-6)
- 3-Bromo-4-(2,2,2-trifluoroethoxy)aniline (CAS 710351-84-1)
- Atogepant Impurity 32 (CAS 1375471-02-5)
- 1-{3-[(1h-imidazol-1-yl)methyl]phenyl}methanamine (CAS 159148-87-5)
- (2S,4S)-Methyl 4-(((benzyloxy)carbonyl)amino)pyrrolidine-2-carboxylate dihydrochloride (CAS 1279038-33-3)
- N-(5-Cyclopropoxy-6-methylpyridin-2-yl)methanesulfonamide (CAS 1243400-01-2)
- rac threo-Dihydro Bupropion-d9 Hydrochloride (CAS CATO-C4X-120341)
- 1-(3,4-Dichlorobenzyl)-1H-pyrazol-4-amine (CAS 895929-62-1)
- 2-Chloro-N-(1-((R)-2,3-dihydroxypropyl)-2-oxo-1,2,3,4-tetrahydroquinolin-3-yl)-6H-thieno[2,3-b]pyrrole-5-carboxamide (CAS 918902-32-6)
- 2-Chloro-5-isopropylbenzonitrile (CAS 1242339-56-5)
- 3-(4-Methylpiperazin-1-yl)-4-(methylsulfonyl)benzoic acid (CAS 1197193-05-7)
- Vonoprazan Impurity 174 (CAS CATO-C4X-1020174)
- Semaglutide impurity 290 (CAS CATO-C4X-2226290)
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