2-Bromo-3-fluoroquinoline-4-carbaldehyde CAS 834884-25-2
| CAS No. | 834884-25-2 |
| Molecular Formula | C10H5BrFNO |
| Molecular Weight | 254.06 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
2-Bromo-3-fluoroquinoline-4-carbaldehyde (CAS 834884-25-2) is a high-purity analytical reference standard with the molecular formula C10H5BrFNO and a molecular weight of 254.06 g/mol.
The molecular framework of 2-Bromo-3-fluoroquinoline-4-carbaldehyde (C10H5BrFNO) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/bromine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
As a certified reference material (CRM), 2-Bromo-3-fluoroquinoline-4-carbaldehyde meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H5BrFNO |
| Molecular Weight | 254.06 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Halogen Content | F/Br-containing |
| Nitrogen Atoms | 1 |
Related Bromo Standards
- 8-Bromo-5-fluoroquinoline-2-carbaldehyde (CAS 1067914-59-3)
- 5-Bromo-4-hydroxypyridine-3-sulfonic acid (CAS 1355216-83-9)
- 8-Bromo-7-fluoroquinoline-4-carbaldehyde (CAS 1420792-02-4)
- 5-Bromo-6-fluoroquinoline-2-carbaldehyde (CAS 1420793-00-5)
- 5-Bromo-8-fluoroquinoline-2-carbaldehyde (CAS 1420793-03-8)
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Recommended Standards
- (2-Fluoro-4-((neopentyloxy)carbonyl)phenyl)boronic acid (CAS 2096329-59-6)
- 3-(Cyclopentyloxy)-2-fluoro-4-methoxyphenylboronic acid (CAS 1793003-66-3)
- 5-Bromo-6-hydroxypyridine-3-sulfonic acid (CAS 577985-06-9)
- 5-Bromo-7-fluoroquinoline-8-carbaldehyde (CAS 2181779-98-4)
- 2-Amino-2-(2-chloro-3-(trifluoromethyl)phenyl)acetic acid (CAS 1270312-86-1)
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- (R)-4,4-difluoro-3-methylpiperidine (CAS 2380769-83-3)
- 1-(2-Thienyl)cyclopropanecarboxylic Acid (CAS 162959-94-6)
- 1-(3-Bromo-5-methoxypyridin-2-yl)ethanone (CAS 1379295-29-0)
- 4-{[3-(Anilinocarbonyl)-1-methyl-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl]methyl}benzoic acid (CAS 1142210-70-5)
- N-Acetyl-D-galactosamine (CAS 1811-31-0)
- 4-(4-(Thiophen-2-yl)pyrimidin-2-yl)phenyl 3-methylbenzoate (CAS 477862-35-4)
- D-Ala18-Tirzepatide (CAS CATO-CPTD788916)
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