4-Chloro-6-methyl-2-(thiophen-2-yl)pyrimidine CAS 83726-83-4
| CAS No. | 83726-83-4 |
| Molecular Formula | C9H7ClN2S |
| Molecular Weight | 210.68 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
4-Chloro-6-methyl-2-(thiophen-2-yl)pyrimidine (CAS 83726-83-4), molecular formula C9H7ClN2S and molecular weight 210.68 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a nitrogen-containing heterocyclic scaffold, a nitrile group, sulfur-containing functionality, chlorine substitution, 4-Chloro-6-methyl-2-(thiophen-2-yl)pyrimidine is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 210.68 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H7ClN2S |
| Molecular Weight | 210.68 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1980 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Chloro Standards
- 3-Chloro-6-(5-methylthiophen-2-yl)pyridazine (CAS 1105194-98-6)
- 4-Chloro-6-methyl-2-(thiophen-3-yl)pyrimidine (CAS 1153298-12-4)
- 4-Chloro-2-(5-methylthiophen-2-yl)pyrimidine (CAS 1155598-46-1)
- 4-Chloro-2-(3-methylthiophen-2-yl)pyrimidine (CAS 1155599-88-4)
- 5-chloro-3-(2-methylphenyl)-1,2,4-thiadiazole (CAS 1221341-18-9)
- 5-Chloro-3-(3-methylphenyl)-1,2,4-thiadiazole (CAS 1221342-38-6)
- 2-Chloro-6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidine (CAS 1225635-21-1)
- 4-Chloro-2-cyclopropylthieno[2,3-d]pyrimidine (CAS 1247422-94-1)
Recommended Standards
- 4-Chloro-6-cyclopropylthieno[3,2-d]pyrimidine (CAS 2306265-43-8)
- 4-Chloro-N-phenylthiazol-2-amine (CAS 912969-54-1)
- 4-Chloro-6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidine (CAS 300816-22-2)
- 5-(2-Chlorophenyl)thiazol-2-amine (CAS 73040-63-8)
- Ethyl(m-tolyl)sulfane (CAS 34786-24-8)
- 1-(2-Chloroethyl)cyclopropane-1-carbonitrile (CAS 1858896-76-0)
- 2-Chloro-4-(2-formylphenyl)benzoic acid (CAS 1261970-85-7)
- N-(5-(2,4-Difluorophenyl)-1,3,4-oxadiazol-2-yl)-2-(3-methoxyphenyl)acetamide (CAS 1171144-49-2)
- (1,3-Dioxoisoindolin-2-yl)methyl 2-((4-methoxyphenyl)thio)acetate (CAS 869714-54-5)
- N-Nitroso-Di-n-Butylamine-d18 (CAS 1219798-82-9)
- Sofinicline (CAS 799279-80-4)
- N-(3-methylpent-1-yn-3-yl)thiophene-2-carboxamide (CAS 664368-42-7)
- Maraviroc RC3 (CAS 1391048-00-2)
- Insulin Degludec Impurity 2 (CAS CATO-C4X-21572)
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