Tolterodine Impurity 19 CAS 837376-36-0
| CAS No. | 837376-36-0 |
| Molecular Formula | C22H31NO |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Tolterodine Impurity 19 (CAS 837376-36-0) is a certified pharmaceutical impurity reference standard with the molecular formula C22H31NOHBr and a molecular weight of 406.41 g/mol.
The molecular framework of Tolterodine Impurity 19 (C22H31NOHBr) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C22H31NO HBr |
| Molecular Weight | 406.41 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related Tolterodine Standards
- Tolterodine Impurity 21 (CAS 1043911-42-7)
- Tolterodine EP Impurity C (CAS 1161940-88-0)
- Tolterodine Impurity N5 (CAS 1189501-90-3)
- Rac- Tolterodine-D14 Hydrochloride (CAS 1246816-99-8)
- rac-Tolterodine-d14 Tartrate (CAS 1246911-91-0)
- Tolterodine Impurity 4 (CAS 124935-88-2)
- Tolterodine Impurity 18 (CAS 124935-89-3)
- rac-Tolterodine hydrochloride, 98% (CAS 124936-75-0)
Recommended Standards
- Cefcapene Impurity 12 Dihydrochloride (CAS 3025716-46-2（free base）)
- Fluvoxamine Impurity 27 (CAS CATO-C4X-195127)
- Glipizide EP Impurity I (CAS 10079-35-3)
- 4'-Methoxy-[1,1'-biphenyl]-4-carbonitrile (CAS 58743-77-4)
- Benzyl (2-(4-(4-chlorophenyl)-1H-imidazol-2-yl)propan-2-yl)carbamate (CAS 1416438-44-2)
- 1-(4-Aminobenzyl)-N-(4-fluoro-2-methylphenyl)-1H-imidazole-4-carboxamide (CAS 1351771-25-9)
- Desoximetasone Impurity 2 (CAS CATO-C4X-16092)
- 5,6,7,8-Tetrahydro-3H-pyrido[4,3-c][1,2,6]thiadiazine 2,2-dioxide hydrochloride (CAS 2138572-96-8)
- 4-(Bromomethyl)-2,3-dichloropyridine (CAS 1227502-62-6)
- Semaglutide Impurity 4 (CAS CATO-C4X-22264)
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