Cetirizine CAS 83881-51-0
| CAS No. | 83881-51-0 |
| Molecular Formula | C21H25ClN2O3 |
| Molecular Weight | 388.89 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Cetirizine (C21H25ClN2O3) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Cetirizine (CAS 83881-51-0), molecular formula C21H25ClN2O3 and molecular weight 388.89 g/mol, is a CATO reference standard with documented purity and traceability.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H25ClN2O3 |
| Molecular Weight | 388.89 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1980 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Cetirizine Standards
- Cetirizine EP Impurity C (CAS 83881-59-8)
- Cetirizine USP Related Compound C (CAS 83881-37-2)
- (±)-Cetirizine-d4 (ethoxy-d4) (CAS 1219803-84-5)
- Cetirizine-d8 (CAS 774596-22-4)
- Cetirizine Impurity 15 (CAS CATO-C4X-158215)
- rac Cetirizine N-Oxide (Mixture of Diastereomers) (CAS 1076199-80-8)
- rac Cetirizine-d8 N-Oxide (CAS 1216444-13-1)
- Cetirizine Impurity 29 (CAS 62084-35-9)
Recommended Standards
- Trazodone impurity 62 (CAS CATO-C4X-177262)
- Bepotastine (CAS 125602-71-3)
- Levocetirizine Impurity 80 (CAS 1232460-31-9)
- H-Ala-Ala-Pro-Val-chloromethylketone (CAS 90105-47-8)
- 4-(4-Bromobenzoyl)-8-propyl-1-oxa-4,8-diazaspiro[4.5]decane-3-carboxylic acid (CAS 1326811-13-5)
- 1-(2-(2-Chlorophenyl)thiazol-5-yl)ethan-1-one (CAS 478047-34-6)
- 4-(6-Chloropyridin-3-yl)thiazol-2-amine (CAS 885279-42-5)
- 3-Chloro-2-(2-methylpropoxy)-4-nitropyridine (CAS 1881329-36-7)
- Tadalafil Impurity 98 (CAS CATO-C4X-108798)
- N-allyl-1H-benzo[d][1,2,3]triazole-1-carbothioamide (CAS 690634-06-1)
- 1-(3-Chloro-4-fluorophenyl)-3-(2-chloroethyl)urea (CAS 848758-99-6)
- 2-(7-Fluoro-6-methylbenzofuran-3-yl)acetic acid (CAS 1420793-16-3)
- 3-[(4-fluorophenyl)methyl]pyrrolidine-2,5-dione (CAS 1267316-35-7)
- Tau Peptide (304-318) trifluoroacetate salt (CAS 330456-49-0)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com