Diphenoxylate Impurity 4 CAS 84255-02-7
| CAS No. | 84255-02-7 |
| Molecular Formula | C19H21NO4S |
| Molecular Weight | 359.44 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Diphenoxylate Impurity 4 (CAS 84255-02-7, C19H21NO4S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Diphenoxylate Impurity 4 (C19H21NO4S) is characterized by a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Diphenoxylate Impurity 4 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C19H21NO4S |
| Molecular Weight | 359.44 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1981 |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Diphenoxylate Standards
- Diphenoxylate Impurity 1 (CAS 24476-55-9)
- Diphenoxylate EP Impurity C (CAS 39186-58-8)
- 【禁售不询】Diphenoxylate Related Compound A CI(Secondary Standards traceble to USP) (CAS 28782-42-5)
- 【禁售不询】Diphenoxylate (CAS 915-30-0)
- Diphenoxylate EP Impurity B (CAS 4370-12-1)
- Diphenoxylate Hydrochloride (CAS 3810-80-8)
Recommended Standards
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- Phentolamine Impurity 25 (CAS CATO-C4X-224725)
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- 2-Amino-N-(2-(dimethylamino)ethyl)-4-methylpentanamide (CAS 740736-93-0)
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