4-(2,6-Dichlorobenzamido)-N-(piperidin-4-yl)-1H-pyrazole-3-carboxamide CAS 844442-38-2
| CAS No. | 844442-38-2 |
| Molecular Formula | C16H17Cl2N5O2 |
| Molecular Weight | 382.24 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 4-(2,6-Dichlorobenzamido)-N-(piperidin-4-yl)-1H-pyrazole-3-carboxamide is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
4-(2,6-Dichlorobenzamido)-N-(piperidin-4-yl)-1H-pyrazole-3-carboxamide (CAS 844442-38-2) is a high-purity analytical reference standard with the molecular formula C16H17Cl2N5O2 and a molecular weight of 382.24 g/mol.
The molecular framework of 4-(2,6-Dichlorobenzamido)-N-(piperidin-4-yl)-1H-pyrazole-3-carboxamide (C16H17Cl2N5O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H17Cl2N5O2 |
| Molecular Weight | 382.24 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 5 |
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Recommended Standards
- 3-(2-(3,5-Dichlorophenyl)hydrazono)-1-phenylindolin-2-one (CAS 303984-75-0)
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- 3-((2,5-Dichlorophenyl)diazenyl)-1-phenyl-1H-indol-2-ol (CAS 303984-76-1)
- N-(2,3-dichlorophenyl)-2-(2-(4-ethylphenoxy)acetyl)hydrazine-1-carboxamide (CAS 893331-99-2)
- Alkyl diphenyl phosphate (CAS 27460-02-2)
- 1-Allyl-5-phenyl-1,3-dihydro-2h-imidazole-2-thione (CAS 332358-13-1)
- 6-Bromo-1,5,7-trimethyl-1,2,3,4-tetrahydro-1,8-naphthyridine (CAS 627098-11-7)
- 7-Hydroxy-4-methylcoumarin-3-acetic acid, SE (CAS 96735-88-5)
- (2S)-2-[(Phenylcarbamoyl)amino]propanoic acid (CAS 93850-62-5)
- 2-Amino-5-isothiocyanatobenzoic acid (CAS 649549-95-1)
- (4-Methylisoxazol-5-yl)methanol (CAS 1607024-83-8)
- 2-(Isochroman-7-yl)acetic acid (CAS 1028666-38-7)
- (S)-2-aminodec-9-enoic acid (CAS 115042-85-8)
- Semaglutide impurity 108 (CAS CATO-C4X-2226108)
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