4-Bromo-N-(3,5-difluorophenyl)benzenesulfonamide CAS 847239-89-8
| CAS No. | 847239-89-8 |
| Molecular Formula | C12H8BrF2NO2S |
| Molecular Weight | 348.16 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
4-Bromo-N-(3,5-difluorophenyl)benzenesulfonamide (CAS 847239-89-8) is a high-purity analytical reference standard with the molecular formula C12H8BrF2NO2S and a molecular weight of 348.16 g/mol.
The molecular framework of 4-Bromo-N-(3,5-difluorophenyl)benzenesulfonamide (C12H8BrF2NO2S) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine/bromine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 4-Bromo-N-(3,5-difluorophenyl)benzenesulfonamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H8BrF2NO2S |
| Molecular Weight | 348.16 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F/Br-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Bromo Standards
- Ethyl 2-bromo-4-(3,5-difluorophenyl)-thiazole-5-carboxylate (CAS 1188123-06-9)
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Recommended Standards
- 7-(2-Bromoethyl)-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine (CAS 377729-85-6)
- Ethyl 3-hydroxy-4-iodobenzo[b]thiophene-2-carboxylate (CAS 2167894-44-0)
- 3-(Perfluorobutyl)-2-hydroxypropyl acrylate (CAS 98573-25-2)
- Ethyl 3-hydroxy-5-iodobenzo[b]thiophene-2-carboxylate (CAS 2168941-73-7)
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