Ethyl 5-fluoro-7-(methylsulfonyl)-1H-indole-2-carboxylate CAS 849035-86-5
| CAS No. | 849035-86-5 |
| Molecular Formula | C12H12FNO4S |
| Molecular Weight | 285.29 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Ethyl 5-fluoro-7-(methylsulfonyl)-1H-indole-2-carboxylate (CAS 849035-86-5), molecular formula C12H12FNO4S and molecular weight 285.29 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of Ethyl 5-fluoro-7-(methylsulfonyl)-1H-indole-2-carboxylate (C12H12FNO4S) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a certified reference material (CRM), Ethyl 5-fluoro-7-(methylsulfonyl)-1H-indole-2-carboxylate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H12FNO4S |
| Molecular Weight | 285.29 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Ethyl Standards
- Ethyl 7-fluoro-5-(methylsulfonyl)-1H-indole-2-carboxylate (CAS 849035-83-2)
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Recommended Standards
- Ethyl 5-cyclopropyl-7-(difluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxylate (CAS 832740-92-8)
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- FAP (CAS 71115-83-8)
- dimethyl 2-(phenylamino)benzene-1,4-dioate (CAS 566155-74-6)
- (S)-Methyl 2-amino-5-guanidinopentanoate hydrochloride (CAS 22888-59-1)
- tert-Butyl 2-(((4-cyanopyridin-2-yl)oxy)methyl)piperidine-1-carboxylate (CAS 1289386-06-6)
- N-(2-aminoethyl)tetrahydrofuran-2-carboxamide (CAS 953735-50-7)
- Methyl 3-[(2-nitrophenyl)amino]propanoate (CAS 38584-59-7)
- 4-Bromoisoquinolin-7-ol (CAS 1783631-45-7)
- 3-(2-Hydroxy-4,4-dimethyl-6-oxocyclohex-1-en-1-yl)-4-oxopentanoic acid (CAS 93647-07-5)
- 3-(Boc-aminomethyl)azetidine Hydrochloride (CAS 1170108-38-9)
- Sitagliptin Impurity 55 (CAS CATO-C4X-114455)
- (+)-3-(2,2-Difluoroacetyl)tetrahydro-2H-pyran-2-one (CAS 183279-72-3)
- Semaglutide Impurity 184 (CAS CATO-C4X-2226184)
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