2,6-dichloro-N-[1-(4-fluorophenyl)-3-(2-thienyl)-1H-pyrazol-5-yl]isonicotinamide CAS 849066-56-4
| CAS No. | 849066-56-4 |
| Molecular Formula | C19H11Cl2FN4OS |
| Molecular Weight | 433.29 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2,6-dichloro-N-[1-(4-fluorophenyl)-3-(2-thienyl)-1H-pyrazol-5-yl]isonicotinamide.
2,6-dichloro-N-[1-(4-fluorophenyl)-3-(2-thienyl)-1H-pyrazol-5-yl]isonicotinamide (CAS 849066-56-4) is a high-purity analytical reference standard with the molecular formula C19H11Cl2FN4OS and a molecular weight of 433.29 g/mol.
The molecular framework of 2,6-dichloro-N-[1-(4-fluorophenyl)-3-(2-thienyl)-1H-pyrazol-5-yl]isonicotinamide (C19H11Cl2FN4OS) is characterized by a steroid core, an amide group, sulfur-containing functionality, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2,6-dichloro-N-[1-(4-fluorophenyl)-3-(2-thienyl)-1H-pyrazol-5-yl]isonicotinamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C19H11Cl2FN4OS |
| Molecular Weight | 433.29 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 4 |
| Sulfur Atoms | 1 |
Related dichloro Standards
- 2-(N-(2,4-dichloro-5-methoxyphenyl)methylsulfonamido)-N-(4-methoxyphenyl)acetamide (CAS 343374-21-0)
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- 1-(2,4-Dichloro-5-methoxyphenyl)-N-(2,6-diethylphenyl)-5-methyl-1H-1,2,4-triazole-3-carboxamide (CAS 339099-60-4)
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Recommended Standards
- Oxaliplatin Impurity 4 (CAS CATO-C4X-27614)
- Ethyl 1-benzyl-5-{[(3,4-dichlorophenyl)carbamoyl]amino}-1h-pyrazole-4-carboxylate (CAS 305337-30-8)
- Ketoconazole impurity 30 (CAS CATO-C4X-147230)
- 3768-14-7 5'-O-[hydroxy(phosphonomethyl)phosphoryl]adenosine Adenosine 5'-(hydrogen (phosphonomethyl)phosphonate) Adenosine, 5'-(trihydrogen methylenebis(phosphonate)) CHEBI:40730 PHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER adenosine 5'-methylenediphosphate (CAS 3768-14-7)
- N-((3-Phenyl-1,2,4-oxadiazol-5-yl)methyl)prop-2-en-1-amine (CAS 890324-00-2)
- N-((1R,3r)-3-aminocyclobutyl)acetamide dihydrochloride (CAS 2206296-41-3)
- 1-Bromohexane-2,2,3,3,4,4,5,5,6,6,6-d11 (CAS 2159-17-3)
- trans-3-Methylamino-1-Boc-4-methoxypyrrolidine (CAS 960316-16-9)
- 5-Methyl-1,3-thiazol-2-ol (CAS 79307-64-5)
- 2-(3-Bromophenyl)-3,4-dihydropyrimidin-4-one (CAS 97604-03-0)
- 1-[(3-chlorophenyl)methyl]cyclopropan-1-amine hydrochloride (CAS 29812-97-3)
- Ethyl 2-amino-3-(3,5-dimethyl-1h-pyrazol-1-yl)propanoate (CAS 1249236-51-8)
- Meropenem Impurity 30 (CAS CATO-C4X-130930)
- Semaglutide impurity 54 (CAS CATO-C4X-222654)
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