Methyl 6-hydroxy-4'-(trifluoromethyl)-[1,1'-biphenyl]-3-carboxylate CAS 849213-77-0
| CAS No. | 849213-77-0 |
| Molecular Formula | C15H11F3O3 |
| Molecular Weight | 296.24 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Methyl 6-hydroxy-4'-(trifluoromethyl)-[1,1'-biphenyl]-3-carboxylate.
Methyl 6-hydroxy-4'-(trifluoromethyl)-[1,1'-biphenyl]-3-carboxylate (CAS 849213-77-0), molecular formula C15H11F3O3 and molecular weight 296.24 g/mol, is a CATO reference standard with documented purity and traceability.
Methyl 6-hydroxy-4'-(trifluoromethyl)-[1,1'-biphenyl]-3-carboxylate (C15H11F3O3) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, a polycyclic aromatic system. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), Methyl 6-hydroxy-4'-(trifluoromethyl)-[1,1'-biphenyl]-3-carboxylate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H11F3O3 |
| Molecular Weight | 296.24 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
Related Methyl Standards
- 6-Hydroxy-2'-(trifluoromethyl)biphenyl-3-carboxylic acid methyl ester (CAS 1261773-15-2)
- Methyl 6-hydroxy-3'-(trifluoromethyl)-[1,1'-biphenyl]-3-carboxylate (CAS 1261822-75-6)
- 4-Hydroxy-2'-methoxy-5'-(trifluoromethyl)-[1,1'-biphenyl]-3-carbaldehyde (CAS 1261953-85-8)
- 2-Hydroxy-4-{[3-(trifluoromethyl)benzyl]oxy}benzenecarbaldehyde (CAS 860611-51-4)
- 3-Hydroxy-2,3-dimethylbutan-2-yl hydrogen (3-cyclopentylthiophen-2-yl)boronate (CAS 1034138-15-2)
- 5-Hydroxy-4-oxo-2-phenyl-4H-chromen-7-yl acetate (CAS 6674-40-4)
- 2-Hydroxy-N-{[3-oxo-2-benzofuran-1(3H)-yliden]methyl}benzenecarbohydrazide (CAS 320424-95-1)
- 7-Hydroxy-N-(5-methylpyridin-2-yl)-2-oxo-2H-chromene-3-carboxamide (CAS 484022-75-5)
Recommended Standards
- Methyl 4-(trifluoromethoxy)-[1,1'-biphenyl]-2-carboxylate (CAS 2379322-71-9)
- N-Benzyl-2-nitro-4-(trifluoromethyl)aniline (CAS 68502-41-0)
- Methyl 2-{[2-(trifluoromethyl)-4-pyridinyl]amino}benzenecarboxylate (CAS 338393-28-5)
- Niflumic Acid EP Impurity F (CAS 59361-45-4)
- 7-(3,5-Dihydro-2H-benzo[e][1,4]dioxepin-3-yl)-7H-purin-6-amine (CAS 918304-44-6)
- 5-Methyl-3-nitro-pyridine-2-thiol (CAS 25391-74-6)
- Methyl 6-chloro-2-methylpyrimidine-4-carboxylate (CAS 1112178-31-0)
- Sulfadimethoxine Impurity 22 (CAS CATO-C4X-150422)
- Ac-Ser-Gly-OH (CAS 3244-65-3)
- 5-((2-Isopropoxyethyl)thio)-1,3,4-thiadiazol-2-amine (CAS 1031201-61-2)
- 5-(2-Methyl-1,3-dioxolan-2-yl)-2-pyridineethanol (CAS 184766-50-5)
- 2-Bromo-6-(tert-butyl)pyridine (CAS 195044-14-5)
- 4-Amino-1-(2-methylcyclopropyl)pyrrolidin-2-one hydrochloride (CAS 1354951-36-2)
- Semaglutide Impurity 124 (CAS CATO-C4X-2226124)
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