2-Hydroxy-4-(trifluoromethoxy)benzoic acid CAS 851341-52-1
| CAS No. | 851341-52-1 |
| Molecular Formula | C8H5F3O4 |
| Molecular Weight | 222.12 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 2-Hydroxy-4-(trifluoromethoxy)benzoic acid is closely related to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
2-Hydroxy-4-(trifluoromethoxy)benzoic acid (CAS 851341-52-1), molecular formula C8H5F3O4 and molecular weight 222.12 g/mol, is a CATO reference standard with documented purity and traceability.
Structurally, 2-Hydroxy-4-(trifluoromethoxy)benzoic acid (C8H5F3O4) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 5.0, corresponding to approximately 5 ring(s) or double-bond equivalent(s). With a molecular weight of 222.12 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 2-Hydroxy-4-(trifluoromethoxy)benzoic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H5F3O4 |
| Molecular Weight | 222.12 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
Related Hydroxy Standards
- 4-Hydroxy-3-(trifluoromethoxy)benzoic acid (CAS 1093397-67-1)
- 2-Hydroxy-5-(trifluoromethoxy)benzoic acid (CAS 129644-57-1)
- 2-Hydroxy-3-(trifluoromethoxy)benzoic acid (CAS 773873-50-0)
- 2-Hydroxy-6-(trifluoromethoxy)benzoic acid (CAS 851341-50-9)
- 3-hydroxy-2-(trifluoromethoxy)benzoic acid (CAS 851341-55-4)
- 4-Hydroxy-2-(trifluoromethoxy)benzoic acid (CAS 851341-56-5)
- 5-Hydroxy-2-(trifluoromethoxy)benzoic acid (CAS 851341-57-6)
- Methyl 2-hydroxy-4-(trifluoromethyl)pyrimidine-5-carboxylate (CAS 886212-78-8)
Recommended Standards
- 2-Bromo-N-isopentylpropanamide (CAS 856078-38-1)
- 2-Nitro-4-(trifluoromethoxy)aniline (CAS 2267-23-4)
- 2-Bromo-N,N-diethylbutanamide (CAS 31457-55-3)
- 2-Nitro-5-(trifluoromethoxy)aniline (CAS 2267-22-3)
- 4-Chloro-5-(difluoromethyl)-2-methylpyridine (CAS 1803709-25-2)
- N-(4-(N-(2-(1H-indol-3-yl)ethyl)sulfamoyl)phenyl)acetamide (CAS 33284-06-9)
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- 3-(2-Aminoacetyl)benzonitrile Hydrochloride (CAS 50916-56-8)
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- tert-Butyl (3-amino-2,3-dimethylbutan-2-yl)carbamate (CAS 1306610-31-0)
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