2,6-Dichloro-3-phenylquinoline CAS 85274-46-0
| CAS No. | 85274-46-0 |
| Molecular Formula | C15H9Cl2N |
| Molecular Weight | 274.14 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2,6-Dichloro-3-phenylquinoline.
2,6-Dichloro-3-phenylquinoline (CAS 85274-46-0), molecular formula C15H9Cl2N and molecular weight 274.14 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 2,6-Dichloro-3-phenylquinoline (C15H9Cl2N) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C15H9Cl2N |
| Molecular Weight | 274.14 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1981 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Dichloro Standards
- 4,6-Dichloro-2-phenylquinoline (CAS 100914-76-9)
- 2,6-Dichloro-4-phenylquinoline (CAS 10352-30-4)
- 2,4-Dichloro-3-phenylquinoline (CAS 108832-15-1)
- 4,7-Dichloro-2-phenylquinoline (CAS 116434-94-7)
- [(2,6-Dichloro-benzyl)-isopropyl-amino]-acetic acid (CAS 1179208-46-8)
- 3,4-Dichloro-N-((1-(hydroxymethyl)cyclopropyl)methyl)benzamide (CAS 1257550-55-2)
- 4,8-Dichloro-2-phenylquinoline (CAS 126530-46-9)
- 2-(4,5-Dichloro-1H-imidazol-1-yl)-N-(furan-2-ylmethyl)acetamide (CAS 1219567-37-9)
Recommended Standards
- 2-(3,4-Dichlorophenyl)-1-(morpholin-4-yl)ethan-1-one (CAS 866134-04-5)
- 2-Chloro-3-(4-chlorophenyl)quinoline (CAS 85274-81-3)
- 2-(3,4-Dichlorobenzyl)-4,4-dimethylisoxazolidin-3-one (CAS 81778-49-6)
- 5-(5-Bromofuran-2-yl)-4-ethyl-4H-1,2,4-triazole-3-thiol (CAS 438229-59-5)
- 2-(5-Bromopyridin-3-yl)benzo[d]oxazole-5-carbohydrazide (CAS 1706434-37-8)
- 1-Bromo-3-fluoropropan-2-ol (CAS 2107-08-6)
- tert-Butyl (2-cyclohexylthiazol-5-yl)carbamate (CAS 1936189-08-0)
- 6-(Bromotriphenyl-l5-phosphanyl)hexanoicacid (CAS 928753-93-9)
- 1-Chloro-2-((4-chlorophenyl)sulfonyl)benzene (CAS 38980-51-7)
- 1-(3-aminophenyl)-N-(butan-2-yl)methanesulfonamide hydrochloride (CAS 1423027-94-4)
- Oxazole, 2,2′-methylenebis[4-[4-(1,1-dimethylethyl)phenyl]-4,5-dihydro-, (4R,4′R)- (CAS 866540-34-3)
- {2-[(4-methylphenyl)sulfanyl]pyridin-3-yl}methyl N-(3,5-dichlorophenyl)carbamate (CAS 338413-54-0)
- Ethyl 2-(4-formylphenyl)acetate (CAS 43153-12-4)
- Insulin Degludec Impurity 25 (CAS CATO-C4X-215725)
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