8-(4-Chloro-2-nitrophenoxy)-2-methylquinoline CAS 852932-31-1
| CAS No. | 852932-31-1 |
| Molecular Formula | C16H11ClN2O3 |
| Molecular Weight | 314.72 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
8-(4-Chloro-2-nitrophenoxy)-2-methylquinoline (CAS 852932-31-1), molecular formula C16H11ClN2O3 and molecular weight 314.72 g/mol, is a CATO reference standard with documented purity and traceability.
Structurally, 8-(4-Chloro-2-nitrophenoxy)-2-methylquinoline (C16H11ClN2O3) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 12.0, corresponding to approximately 12 ring(s) or double-bond equivalent(s). With a molecular weight of 314.72 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H11ClN2O3 |
| Molecular Weight | 314.72 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
- 2-chloro-3-(2-nitrophenoxymethyl)quinoline (CAS 105271-81-6)
- 3-((8-Chloro-4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoic acid (CAS 1174044-69-9)
- 7-Chloro-6-((3-methoxyphenyl)amino)quinoline-5,8-dione (CAS 147116-42-5)
- (3Z)-3-[(4-Chloro-3-nitrophenyl)methylidene]-1-methyl-2,3-dihydro-1H-indol-2-one (CAS 565426-54-2)
- 2-(1-(3-Chloro-4-fluorobenzoyl)-4-fluoropiperidin-4-yl)-2-hydroxyacetonitrile (CAS 448920-98-7)
- 3-(3-Chloro-4-methylphenyl)-4-oxo-3,4-dihydrophthalazine-1-carboxylic acid (CAS 926201-05-0)
- 4-Chloro-N-(5-methyl-2-oxo-2H-pyrano[3,2-c]pyridin-3-yl)benzamide (CAS 341966-08-3)
- 4-Chloro-N'-{[(1Z)-3-oxo-1,3-dihydro-2-benzofuran-1-ylidene]methyl}benzohydrazide (CAS 320424-84-8)
Recommended Standards
- 7-(Benzyloxy)-4-chloro-3-nitroquinoline (CAS 749922-36-9)
- Diethyl 2-(2-chloronicotinamido)malonate (CAS 219793-85-8)
- 6-(Benzyloxy)-4-chloro-3-nitroquinoline (CAS 847577-91-7)
- Ethyl 1-(6-chloro-5-nitropyrimidin-4-yl)piperidine-4-carboxylate (CAS 733747-96-1)
- (1R,2S,3R,4R,6R)-4-(((tert-Butyldiphenylsilyl)oxy)methyl)-6-methoxycyclohexane-1,2,3-triol (CAS 143249-53-0)
- 5,6-Dihydro-4H-1,3-oxazin-2-amine (CAS 1848-68-6)
- 6-Chloro-5-iodo-3-nitropyridin-2-amine (CAS 790692-90-9)
- Canagliflozin Impurity 24 (CAS 2348-31-4)
- 2-((2-Hydroxyethyl)thio)-1-(p-tolyl)propan-1-one (CAS 1157217-54-3)
- 1-(2-Benzonitrile)piperazine (CAS 111373-03-6)
- Ethyl 6-chloro-2-oxo-2H-chromene-3-carboxylate (CAS 70384-80-4)
- 5-Bromo-2-(3-methylphenoxy)aniline (CAS 946786-77-2)
- 1-(2-Methoxyphenyl)-2-methylbutan-1-one (CAS 1196852-29-5)
- Semaglutide Impurity 138 (CAS CATO-C4X-2226138)
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