Ethyl 2-(2-chloro-4-fluorophenyl)acetate CAS 853301-97-0
| CAS No. | 853301-97-0 |
| Molecular Formula | C10H10ClFO2 |
| Molecular Weight | 216.64 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Ethyl 2-(2-chloro-4-fluorophenyl)acetate (CAS 853301-97-0), molecular formula C10H10ClFO2 and molecular weight 216.64 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of Ethyl 2-(2-chloro-4-fluorophenyl)acetate (C10H10ClFO2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures Ethyl 2-(2-chloro-4-fluorophenyl)acetate under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C10H10ClFO2 |
| Molecular Weight | 216.64 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F/Cl-containing |
Related Ethyl Standards
- 3-(2-Chloro-6-fluorophenyl)-2-methylpropanoic acid (CAS 1017208-40-0)
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Recommended Standards
- Benzofuran-5-sulfonyl chloride (CAS 869885-60-9)
- Ethyl 2-(2-Chloro-6-fluorophenyl)acetate (CAS 214262-85-8)
- Benzofuran-4-sulfonyl chloride (CAS 479028-64-3)
- Ethyl 2-(3-Chloro-4-fluorophenyl)acetate (CAS 340825-20-9)
- 1142204-72-5 9314AC C18H20N2O4 [{2-[(2-Methoxybenzyl)amino]-2-oxoethyl}(phenyl)-amino]acetic acid (CAS 1142204-72-5)
- Bis(3-fluorophenyl)methanol (CAS 98586-21-1)
- 5-Methyl-3-phenyl-1,2-thiazole-4-carboxylic acid (CAS 13950-59-9)
- 1-(2-Bromobenzoyl)piperidine-4-carboxamide (CAS 425609-05-8)
- Methyl 2-amino-5-fluoronicotinate (CAS 1211535-54-4)
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- 1-(Naphthalen-1-yl)isoquinoline (CAS 66920-31-8)
- 2-(Chloromethyl)-5-ethylpyridine (CAS 10447-76-4)
- Semaglutide impurity 331 (CAS CATO-C4X-2226231)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com