3-(2-Chloro-3-methoxyphenyl)propanoic acid CAS 853331-56-3
| CAS No. | 853331-56-3 |
| Molecular Formula | C10H11ClO3 |
| Molecular Weight | 214.65 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 214.65 g/mol gives 3-(2-Chloro-3-methoxyphenyl)propanoic acid distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
3-(2-Chloro-3-methoxyphenyl)propanoic acid (CAS 853331-56-3) is a high-purity analytical reference standard with the molecular formula C10H11ClO3 and a molecular weight of 214.65 g/mol.
The molecular framework of 3-(2-Chloro-3-methoxyphenyl)propanoic acid (C10H11ClO3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H11ClO3 |
| Molecular Weight | 214.65 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl-containing |
Related Chloro Standards
- 4-Chloro-1-cyclopentyl-1H-pyrazole-3-carboxylic acid (CAS 1006451-33-7)
- 2-(4-Chloro-3-cyclopropyl-1h-pyrazol-1-yl)propanoic acid (CAS 1006490-23-8)
- 4-Chloro-1-cyclopentyl-1h-pyrazole-5-carboxylic acid (CAS 1006493-95-3)
- 6-Chloro-N-(2-methoxyethyl)pyridine-3-carboxamide (CAS 1016741-22-2)
- 2-Chloro-5-phenylnicotinonitrile (CAS 10177-10-3)
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Recommended Standards
- 2-Ethoxy-3-methoxybenzoyl chloride (CAS 23966-83-8)
- 3-(2-Chloro-4-methylphenoxy)propanoic acid (CAS 40629-78-5)
- 2-Chloro-N-methoxy-N,6-dimethylisonicotinamide (CAS 329946-08-9)
- 3-(4-chloro-3-methoxyphenyl)propanoic acid (CAS 475654-42-3)
- 5-Ethoxy-2-phenylbenzofuran-3-carboxylic acid (CAS 300674-08-2)
- 3-Bromo-1-(4-methylbenzenesulfonyl)imidazo[1,5-a]pyridine (CAS 904813-34-9)
- 3-Bromo-2-iodo-5-methylpyridine (CAS 1211542-16-3)
- (3-(2,5-Dimethoxybenzyl)furan-2-yl)methanamine (CAS 626205-86-5)
- 1-(3-azidopropyl)pyrrolidine (CAS 1248112-95-9)
- (3-(Aminomethyl)pyrrolidin-1-yl)(3-bromo-2-methylphenyl)methanone (CAS 1838339-29-9)
- 2-(4-(Difluoromethyl)-5-iodo-2-methylpyridin-3-yl)acetic acid (CAS 1806857-53-3)
- 2-(2-(2-((3-(3-(Tert-butyl)-4-hydroxy-5-methylphenyl)propanoyl)oxy)ethoxy)ethoxy)ethyl 3-(3-(tert-butyl)-4-methoxy-5-methylphenyl)propanoate (CAS CATO-C3D-4506)
- 4-Methyl-6-styrylpyrimidin-5-ol (CAS 791539-01-0)
- Semaglutide Impurity 5 (CAS 23406-82-8)
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