Trelagliptin Impurity N51 CAS 853368-35-1
| CAS No. | 853368-35-1 |
| Molecular Formula | C8H5BrFN |
| Molecular Weight | 214.03 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 214.03 g/mol gives Trelagliptin Impurity N51 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Trelagliptin Impurity N51 (CAS 853368-35-1) is a certified pharmaceutical impurity reference standard with the molecular formula C8H5BrFN and a molecular weight of 214.03 g/mol.
The molecular framework of Trelagliptin Impurity N51 (C8H5BrFN) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/bromine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Trelagliptin Impurity N51 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H5BrFN |
| Molecular Weight | 214.03 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F/Br-containing |
| Nitrogen Atoms | 1 |
Related Trelagliptin Standards
- Trelagliptin Impurity 9 (CAS 222978-03-2)
- Trelagliptin Impurity 54 (CAS 1261686-95-6)
- Trelagliptin Impurity 55 (CAS 635723-84-1)
- Trelagliptin Impurity 23 (CAS 309956-78-3)
- Trelagliptin Impurity 64 (CAS CATO-C4X-104664)
- Trelagliptin Impurity 12 (CAS CATO-C4X-104612)
- Trelagliptin Impurity 43 (CAS 1515699-87-2)
- Trelagliptin Impurity 54 (CAS 389623-44-3)
Recommended Standards
- 3-(Bromomethyl)-4-fluorobenzonitrile (CAS 856935-35-8)
- 3-Bromo-2-fluorophenylacetonitrile (CAS 874285-03-7)
- 2-Bromo-6-fluorophenylacetonitrile, 97% (CAS 936693-22-0)
- 3-Bromo-4-Fluorobenzylisocyanide (CAS 728920-04-5)
- Testosterone Impurity 4 (CAS CATO-C4X-24324)
- Letermovir impurity 56 (CAS CATO-C4X-291556)
- Ibrutinib Impurity 25 (CAS CATO-C4X-106425)
- 1-(6-(2H-1,2,3-Triazol-2-yl)-5-(trifluoromethyl)pyridin-3-yl)-3-(7-(cyclopropyl(dimethylamino)methyl)-2-methylthiazolo[5,4-b]pyridin-6-yl)urea (CAS 2178991-05-2)
- 1-chloro-4-(chloromethyl)-2,3-difluorobenzene (CAS 1807133-11-4)
- 5,7-Dihydroxy-2,2-dimethyl-4H-1,3-benzodioxin-4-one (CAS 137571-73-4)
- 4-(2-Bromo-9-(4-(tert-butyl)phenyl)-9H-fluoren-9-yl)phenol (CAS 849222-40-8)
- 5,8-Diphenyl-3-(trifluoromethyl)pyrido[2,3-d]pyridazine (CAS 339106-51-3)
- 2-Methylhex-5-enoic acid (CAS 77290-89-2)
- [3-31]-Semaglutide D (Sodium salt) (CAS CATO-C4X-2226119)
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