2-Chloro-4-methylthiophene-3-carboxylic Acid CAS 85345-22-8
| CAS No. | 85345-22-8 |
| Molecular Formula | C6H5ClO2S |
| Molecular Weight | 176.62 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2-Chloro-4-methylthiophene-3-carboxylic Acid (CAS 85345-22-8), molecular formula C6H5ClO2S and molecular weight 176.62 g/mol, is a CATO reference standard with documented purity and traceability.
2-Chloro-4-methylthiophene-3-carboxylic Acid (C6H5ClO2S) contains a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 2-Chloro-4-methylthiophene-3-carboxylic Acid under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C6H5ClO2S |
| Molecular Weight | 176.62 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1981 |
| Halogen Content | Cl-containing |
| Sulfur Atoms | 1 |
Related Chloro Standards
- 4-Chloro-5-methylthiophene-2-carboxylic acid (CAS 123418-43-9)
- 2-Chloro-5-methylthiazole-4-carboxamide (CAS 1379296-94-2)
- 2-Chloro-1-(4-methyl-1,2,3-thiadiazol-5-yl)ethan-1-one (CAS 1504719-85-0)
- (Z)-5-chloro-n'-hydroxythiophene-2-carboximidamide (CAS 90981-26-3)
- 2-Chloro-4-methylthiazole-5-carboxamide (CAS 856658-33-8)
- 2-chloro-5-fluoro-4-prop-1-ynyl-pyrimidine (CAS 2748015-16-7)
- 2-Chloro-5-methylthiophene-3-carboxylic acid (CAS 54494-61-0)
- 2-Chloro-N-(1,3-thiazol-2-yl)acetamide (CAS 5448-49-7)
Recommended Standards
- 2-Acetamido-5-chlorothiazolev (CAS 20256-39-7)
- 1-(4-Amino-2-chlorothiazol-5-yl)ethanone (CAS 1895032-13-9)
- 3-Chloro-4-methylthiophene-2-carboxylic acid (CAS 229342-86-3)
- 2-(2-Chlorothiazol-5-yl)acetamide (CAS 1823943-81-2)
- 2-[3-(methoxymethoxy)-1-naphthyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 2378262-52-1)
- 2-(2-Fluorophenoxy)-N-(2-(3-(pyridin-4-yl)-1H-pyrazol-1-yl)ethyl)acetamide (CAS 1448060-12-5)
- 3-(4-Fluorobenzyl)piperidine (CAS 382637-47-0)
- 3,3,4,4-Tetrafluoro-1,5-hexadiene (CAS 1763-21-9)
- tert-Butyl (6-chloro-4-(1-hydroxyethyl)pyridin-3-yl)carbamate (CAS 1382848-43-2)
- 1,6,7-Trimethyl-3-pentyloxazolo[2,3-f]purine-2,4(1H,3H)-dione (CAS 899997-36-5)
- 3-(3-Phenoxypropoxy)azetidine (CAS 1339412-77-9)
- 4-Acetamido-5-nitro-m-xylene (CAS 606-38-2)
- 5,6,7,8-Tetrahydroquinoline-8-carbonitrile (CAS 53400-61-6)
- Insulin Degludec Impurity 24 (CAS CATO-C4X-215724)
Why CATO?
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