1-(3-Chloropyridin-2-yl)piperazine hydrochloride CAS 85386-86-3
| CAS No. | 85386-86-3 |
| Molecular Formula | C9H12ClN3 |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 1-(3-Chloropyridin-2-yl)piperazine hydrochloride.
1-(3-Chloropyridin-2-yl)piperazine hydrochloride (CAS 85386-86-3), molecular formula C9H12ClN3HCl and molecular weight 234.12 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 1-(3-Chloropyridin-2-yl)piperazine hydrochloride (C9H12ClN3HCl) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H12ClN3 HCl |
| Molecular Weight | 234.12 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1981 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Chloropyridin Standards
- 3-(2-Chloropyridin-3-yl)propan-1-amine (CAS 1000512-13-9)
- 2-(4-chloropyridin-2-yl)acetonitrile (CAS 1000515-40-1)
- 2-(5-Chloropyridin-2-yl)acetic acid (CAS 1000522-43-9)
- 3-(6-Chloropyridin-3-yl)propan-1-amine (CAS 1000543-63-4)
- 3-(2-Chloropyridin-4-yl)propan-1-amine (CAS 1000545-70-9)
- 2-(3-Chloropyridin-4-yl)acetic acid (CAS 1000553-75-2)
- 3-(3-Chloropyridin-4-yl)propan-1-amine (CAS 1000555-79-2)
- 2-(4-Chloropyridin-3-yl)acetic acid (CAS 1000567-15-6)
Recommended Standards
- 5-Methyl-2-propoxybenzaldehyde (CAS 883531-97-3)
- 5-Chloro-3-methyl-2,3-dihydro-1h-indole (CAS 905274-08-0)
- 2-Fluorobenzaldehyde oxime (CAS 451-79-6)
- 3,5-Dimethyl-1H-pyrazole-4-carbonitrile (CAS 108161-12-2)
- Methyl 2-(3-ethoxyphenyl)-2-hydroxyacetate (CAS 1250699-70-7)
- Ethyl 4-chloroquinoline-2-carboxylate (CAS 18436-69-6)
- Difluoromethyl 3-methylphenyl sulphone (CAS 4837-16-5)
- 2-(2-Amino-6-(difluoromethyl)-4-iodopyridin-3-yl)acetonitrile (CAS 1806894-53-0)
- 4-Ethyl-2-methylaniline hydrochloride (CAS 1201943-82-9)
- Brain Injury Derived Neurotrophic Peptide (H-3914.0001) (CAS 148330-12-5)
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