2-(Benzofuran-3-yl)acetyl chloride CAS 857283-98-8
| CAS No. | 857283-98-8 |
| Molecular Formula | C10H7ClO2 |
| Molecular Weight | 194.61 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
2-(Benzofuran-3-yl)acetyl chloride (CAS 857283-98-8), molecular formula C10H7ClO2 and molecular weight 194.61 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system, 2-(Benzofuran-3-yl)acetyl chloride is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 194.61 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H7ClO2 |
| Molecular Weight | 194.61 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl-containing |
Related Benzofuran Standards
- 1-(Benzofuran-3-yl)-2-chloroethanone (CAS 102878-09-1)
- 2-(Benzofuran-2-yl)acetyl chloride (CAS 86790-43-4)
- 3-Methyl-benzofuran-2-carbonyl chloride (CAS 2256-86-2)
- 6-Phenyl-1-benzofuran (CAS 35664-69-8)
- Benzofuran-5-yldimethylphosphine oxide (CAS 2748288-54-0)
- Benzofuran-6-yldimethylphosphine oxide (CAS 2260682-20-8)
- 2-(Benzofuran-2-yl)pyridine (CAS 7035-05-4)
- 1-(Benzofuran-2-yl)-2,2-difluoroethanone (CAS 181059-88-1)
Recommended Standards
- 2-chloro-1-[3-(difluoromethyl)-1-bicyclo[1.1.1]pentanyl]ethanone (CAS 2573212-74-3)
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- 2-chloro-3,4-dihydroxy-benzoic acid (CAS 87932-50-1)
- 6-Chloro-5-fluoro-2-(methylthio)pyrimidin-4(3H)-one (CAS 1934640-63-7)
- N-Nitroso Compounds 33 (CAS 28571-11-1)
- 2-Chloro-6-(3-methyl-1-piperidinyl)pyrazine (CAS 1219967-42-6)
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- 2-Acetyl-5-bromobenzofuran-4,7-dione (CAS 1389264-29-2)
- 7-(4-(Tert-butyl)phenyl)-7-oxoheptanoic acid (CAS 898791-45-2)
- 6,7-Dihydro-4H-pyrano[3,4-d]thiazol-2-amine (CAS 1065641-40-8)
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