6-Amino-2-(4-chlorophenyl)pyrimidine-4-carboxylic acid CAS 858956-28-2
| CAS No. | 858956-28-2 |
| Molecular Formula | C11H8ClN3O2 |
| Molecular Weight | 249.65 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), 6-Amino-2-(4-chlorophenyl)pyrimidine-4-carboxylic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
6-Amino-2-(4-chlorophenyl)pyrimidine-4-carboxylic acid (CAS 858956-28-2) is a high-purity analytical reference standard with the molecular formula C11H8ClN3O2 and a molecular weight of 249.65 g/mol.
6-Amino-2-(4-chlorophenyl)pyrimidine-4-carboxylic acid (C11H8ClN3O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C11H8ClN3O2 |
| Molecular Weight | 249.65 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Amino Standards
- 2-Amino-4-(2-chlorophenyl)pyrimidine-5-carboxylic acid (CAS 1820705-80-3)
- 2-Amino-4-(4-chlorophenyl)pyrimidine-5-carboxylic acid (CAS 1820710-58-4)
- 4-Amino-5-chloro-[2,4'-bipyridine]-6-carboxylic acid (CAS 496852-27-8)
- (2-Amino-5-chloro-4-fluorophenyl)(phenyl)methanone (CAS 1433904-07-4)
- (2-Amino-4-chlorophenyl)(2-fluorophenyl)methanone (CAS 203303-05-3)
- (2-Amino-5-chlorophenyl)(4-fluorophenyl)methanone (CAS 784-40-7)
- 2-Amino-5-(aminosulfonyl)-4-chlorobenzamide (CAS 34121-17-0)
- 4-(2-Amino-2-oxoethoxy)benzenesulfonyl chloride (CAS 69986-21-6)
Recommended Standards
- 6-(4-Chlorophenoxy)pyridine-2-carboxylic acid (CAS 51362-41-5)
- 6-Chloro-3-nitro-5-phenylpyridin-2-amine (CAS 790692-86-3)
- 6-(4-Chlorophenoxy)nicotinic acid (CAS 51362-39-1)
- 6-Chloro-3-nitro-N-phenylpyridin-2-amine (CAS 26867-13-0)
- (3S)-1-Ethylpyrrolidin-3-amine (CAS 216667-65-1)
- 2-(2-(Phenylthio)pyridin-3-yl)piperidine-1-carbaldehyde (CAS 1352514-87-4)
- Ethyl 2,3-dihydro-1H-imidazo[1,2-b]pyrazole-7-carboxylate (CAS 1378779-72-6)
- 1-(2-(6-Chloropyridin-3-yl)piperidin-1-yl)ethan-1-one (CAS 1352527-38-8)
- Oxo Sotalol-d6 Hydrochloride (CAS 1346605-37-5)
- Octyl 3-oxobutanoate (CAS 16436-00-3)
- 6,6-Difluorobicyclo[3.1.0]hexane-3-carbaldehyde (CAS 494210-62-7)
- N-(2-(1H-Imidazo[1,2-b]pyrazol-1-yl)ethyl)-1-(thiophen-2-yl)cyclopentane-1-carboxamide (CAS 1797628-80-8)
- 5-(Trifluoromethyl)-2h-spiro[benzofuran-3,4'-piperidine] hydrochloride (CAS 2197056-63-4)
- Des-Trp25-Tirzepatide (CAS CATO-CPTD788948)
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