(E)-3-(3-chloro-4-methoxyphenyl)-1-(4-fluorophenyl)prop-2-en-1-one CAS 861207-59-2

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including (E)-3-(3-chloro-4-methoxyphenyl)-1-(4-fluorophenyl)prop-2-en-1-one.

(E)-3-(3-chloro-4-methoxyphenyl)-1-(4-fluorophenyl)prop-2-en-1-one (CAS 861207-59-2), molecular formula C16H12ClFO2 and molecular weight 290.72 g/mol, is a CATO reference standard with documented purity and traceability.

The molecular framework of (E)-3-(3-chloro-4-methoxyphenyl)-1-(4-fluorophenyl)prop-2-en-1-one (C16H12ClFO2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, a polycyclic aromatic system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

CATO manufactures (E)-3-(3-chloro-4-methoxyphenyl)-1-(4-fluorophenyl)prop-2-en-1-one under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.

Physical & Chemical Properties

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