Atomoxetine impurity 43 CAS 861381-14-8
| CAS No. | 861381-14-8 |
| Molecular Formula | C10H12N2O2 |
| Molecular Weight | 192.21 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Based on its molecular formula C10H12N2O2, Atomoxetine impurity 43 contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 192.21 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
As a process- or degradation-related impurity, Atomoxetine impurity 43 (CAS 861381-14-8, C10H12N2O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Atomoxetine impurity 43 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H12N2O2 |
| Molecular Weight | 192.21 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Nitrogen Atoms | 2 |
Related Atomoxetine Standards
- Atomoxetine Impurity 48 (CAS CATO-C4X-155048)
- Atomoxetine Impurity 9 HCl (CAS 1011-59-2)
- Atomoxetine EP Impurity H (S-Isomer) (CAS 114133-37-8)
- Atomoxetine EP Impurity H (R-Isomer) (CAS 115290-81-8)
- Atomoxetine Impurity 25 (CAS CATO-C4X-155025)
- Atomoxetine Hydrochloride EP Impurity E (CAS 17199-29-0)
- Atomoxetine Impurity 13 (CAS 60960-88-5)
- Atomoxetine impurity 01 (CAS 109306-10-7)
Recommended Standards
- Zolpidem Tartrate EP Impurity C (CAS 4619-20-9)
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- Methyldopa Impurity 13 (CAS 94782-89-5)
- Iopamidol Impurity 41 (CAS CATO-C4X-145041)
- Dexamethasone Sodium Phosphate Impurity 47 (CAS CATO-C4X-116547)
- Levetiracetam Impurity 46 (CAS CATO-C4X-106746)
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- 2-Chloro-6-(difluoromethyl)-4-(trifluoromethyl)nicotinaldehyde (CAS 1805369-36-1)
- 3-(2-Chloroethyl)-2-((2-chloroethyl)amino)-4-hydroxy-1,3,2-oxazaphosphinane 2-oxide (CAS 50892-10-9)
- 5-Chloro-N-(furan-2-ylmethyl)thiophene-2-sulfonamide (CAS 380576-68-1)
- 2-Bromo-5-(chlorosulfonyl)benzoic acid (CAS 3285-31-2)
- Polymyxin B nonapeptide (CAS 86408-36-8)
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