5-Cyclopropyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid CAS 861408-98-2
| CAS No. | 861408-98-2 |
| Molecular Formula | C11H8F3N3O2 |
| Molecular Weight | 271.20 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
5-Cyclopropyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (CAS 861408-98-2) is a high-purity analytical reference standard with the molecular formula C11H8F3N3O2 and a molecular weight of 271.20 g/mol.
Structurally, 5-Cyclopropyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (C11H8F3N3O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 8.0, corresponding to approximately 8 ring(s) or double-bond equivalent(s). With a molecular weight of 271.20 g/mol, it falls into the medium-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a certified reference material (CRM), 5-Cyclopropyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H8F3N3O2 |
| Molecular Weight | 271.20 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Cyclopropyl Standards
- 7-Cyclopropyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-5-carboxylic acid (CAS 1781023-09-3)
- 5-Cyclopropyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-7-carboxylic acid (CAS 1795475-02-3)
- 5-Cyclopropyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxylic acid (CAS 436088-48-1)
- 7-Cyclopropyl-2,3-dihydro-[1,4]dioxino[2,3-g]quinoline-9-carboxylic acid (CAS 923750-34-9)
- Ethyl 3-(cyclopropyl(3-ethoxy-3-oxopropyl)amino)-3-oxopropanoate (CAS 1453423-54-5)
- 2-cyclopropyl-7,8,9,10-tetrahydro-6H-pyrido[3’,2’:4,5]imidazo[1,2-a]azepine-4-carboxylic acid (CAS 949984-41-2)
- 6-cyclopropyl-1-(1-cyclopropylethyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid (CAS 954254-86-5)
- 4-Cyclopropyl-5-(ethylsulfonyl)-1H-thieno[2,3-c]pyrazol-3-amine (CAS 1707393-93-8)
Recommended Standards
- 5-Methyl-1-(3-(trifluoromethyl)phenyl)-1h-1,2,3-triazole-4-carboxylic acid (CAS 499771-21-0)
- 5-Bromo-4-(6-methylheptyl)pyrimidine (CAS 951884-24-5)
- 5-Methyl-1-(4-nitrophenyl)-3-(trifluoromethyl)-1H-pyrazole (CAS 374814-09-2)
- 5-Amino-1-(3-(trifluoromethyl)phenyl)-1H-1,2,3-triazole-4-carboxamide (CAS 924862-08-8)
- 5,7-Difluoro-2-(pyridin-2-yl)indoline (CAS 591721-07-2)
- 4-[(4-Chlorobenzyl)amino]benzoic acid (CAS 63759-94-4)
- 2-(Difluoromethyl)-5-iodo-3-(trifluoromethoxy)-4-(trifluoromethyl)pyridine (CAS 1804358-99-3)
- 3,5-Bis(2-methylphenyl)-1H-1,2,4-triazole (CAS 85681-49-8)
- 6-Chloro-1H-pyrrolo[3,2-b]pyridin-5-amine (CAS 2231673-96-2)
- 7-Bromo-5-chloro-1H-benzotriazole (CAS 1086836-82-9)
- Met-Lys-Bradykinin (CAS 550-19-6)
- 4-((Azetidin-3-yloxy)methyl)-1-ethyl-1h-pyrazole (CAS 1339675-51-2)
- Ciprofloxacin Impurity 15 (CAS 86483-53-6)
- Peptide 438 (CAS CATO-CPTD788438)
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