5-Cyclopropyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carbonyl chloride CAS 861452-41-7
| CAS No. | 861452-41-7 |
| Molecular Formula | C11H7ClF3N3O |
| Molecular Weight | 289.64 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 5-Cyclopropyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carbonyl chloride is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
5-Cyclopropyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carbonyl chloride (CAS 861452-41-7) is a high-purity analytical reference standard with the molecular formula C11H7ClF3N3O and a molecular weight of 289.64 g/mol.
Structurally, 5-Cyclopropyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carbonyl chloride (C11H7ClF3N3O) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 8.0, corresponding to approximately 8 ring(s) or double-bond equivalent(s). With a molecular weight of 289.64 g/mol, it falls into the medium-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 5-Cyclopropyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carbonyl chloride meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H7ClF3N3O |
| Molecular Weight | 289.64 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related Cyclopropyl Standards
- 5-Cyclopropyl-7-trifluoromethyl-pyrazolo-[1,5-a]pyrimidine-2-carbonyl chloride (CAS 861452-42-8)
- N-Cyclopropyl-2,5-dimethyl-N-(2-(thiophen-2-yl)ethyl)furan-3-carboxamide (CAS 1396806-59-9)
- 2-[(4-benzyl-5-cyclopropyl-4h-1,2,4-triazol-3-yl)sulfanyl]acetic acid (CAS 852400-25-0)
- n-Cyclopropyl-2-[4-oxo-2-(phenylimino)-1,3-thiazolidin-5-yl]acetamide (CAS 871909-80-7)
- Ethyl 3-cyclopropyl-6-hydroxy-1-propyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylate (CAS 1174839-56-5)
- Cyclopropyl(4-(4-nitrophenyl)-1,4-diazepan-1-yl)methanone (CAS 1286728-06-0)
- N-Cyclopropyl-2-(2,5-dioxopyrrolidin-1-yl)-N-((1-methyl-1H-pyrrol-2-yl)methyl)acetamide (CAS 1286728-96-8)
- N-Cyclopropyl-3-(1H-indol-4-yl)imidazo[1,2-a]pyrazin-8-amine (CAS 825630-54-4)
Recommended Standards
- 5-Amino-4-chloro-2-(4-(trifluoromethyl)phenyl)pyridazin-3(2H)-one (CAS 24181-95-1)
- 5-(4-Chlorophenyl)-2-(trifluoromethyl)furan-3-carboxamide (CAS 2197053-72-6)
- 6-(Chloromethyl)-2-(5-(trifluoromethyl)pyridin-2-yl)pyrimidin-4-ol (CAS 266679-42-9)
- 4-Amino-5-chloro-2-(4-(trifluoromethyl)phenyl)pyridazin-3(2H)-one (CAS 923027-45-6)
- 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)quinoline-6-carbaldehyde (CAS 958852-17-0)
- (2S)-1-methyl-2-(propan-2-yl)piperazine hydrochloride (CAS 2059912-12-6)
- 2-Methyl-4-phenyl-5-(pyridin-4-yl)oxazole (CAS 318480-82-9)
- 1-(4-Methyl-piperidin-1-ylmethyl)-propylamine (CAS 883543-40-6)
- Letrozole Impurity 20 (CAS CATO-C4X-182920)
- 2-[(4-Methoxyphenyl)methanesulfonyl]-4,5-diphenyl-1-(prop-2-yn-1-yl)-1H-imidazole (CAS 339277-83-7)
- N1-(4-methoxybenzyl)propane-1,3-diamine (CAS 106353-11-1)
- N-((1-Cyclohexyl-1H-tetrazol-5-yl)methyl)pentanamide (CAS 921502-79-6)
- (R)-3-((tert-Butoxycarbonyl)amino)-3-(2,4,5-trimethoxyphenyl)propanoic acid (CAS 1260587-08-3)
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