Tranexamic Impurity 22 CAS 861518-79-8
| CAS No. | 861518-79-8 |
| Molecular Formula | C16H13ClO4 |
| Molecular Weight | 304.73 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Tranexamic Impurity 22.
Tranexamic Impurity 22 (CAS 861518-79-8) is a certified pharmaceutical impurity reference standard with the molecular formula C16H13ClO4 and a molecular weight of 304.73 g/mol.
The molecular framework of Tranexamic Impurity 22 (C16H13ClO4) is characterized by a flavonoid core, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Tranexamic Impurity 22 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H13ClO4 |
| Molecular Weight | 304.73 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl-containing |
Related Tranexamic Standards
- Tranexamic Acid Impurity 20 (CAS 2682114-50-5)
- Tranexamic Acid EP Impurity A (CAS 93940-19-3)
- Tranexamic Impurity 40 (CAS 2469781-80-2)
- Tranexamic Acid EP Impurity E (CAS 82755-59-7)
- Tranexamic Acid Impurity 32 (CAS CATO-C4X-177132)
- Tranexamic Impurity 35 (CAS CATO-C4X-177135)
- Tranexamic Impurity 42 (CAS CATO-C4X-177142)
- Tranexamic Impurity 28 (CAS CATO-C4X-177128)
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