Simvastatin EP Impurity J CAS 864357-88-0
| CAS No. | 864357-88-0 |
| Molecular Formula | C26H40O5 |
| Molecular Weight | 432.59 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Simvastatin EP Impurity J is closely related to a steroid core, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies Simvastatin EP Impurity J (CAS 864357-88-0), a pharmacopoeial impurity reference standard (molecular formula C26H40O5, MW 432.59 g/mol) used for the identification and quantification of trace impurities in APIs.
Simvastatin EP Impurity J (C26H40O5) contains a steroid core, a hydroxyl group, an ether linkage. The carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Simvastatin EP Impurity J meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C26H40O5 |
| Molecular Weight | 432.59 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
Related Simvastatin Standards
- Simvastatin EP Impurity N (Mixture of Diastereomers) (CAS 774611-54-0)
- Simvastatin Impurity 8 (CAS 130468-11-0)
- Simvastatin-d11 (CAS 1002347-74-1)
- Simvastatin-d6 (CAS 1002347-71-8)
- Simvastatin D3 (CAS 1002347-61-6)
- Simvastatin EP Impurity K (CAS CATO-C4X-119913)
- Simvastatin Impurity 26 (CAS CATO-C4X-119926)
- Simvastatin Impurity 27 (CAS 132487-01-5)
Recommended Standards
- Tetrakis(4-ethynylphenyl)silane (CAS 1390641-82-3)
- 5-Ethyl-N-(1-(thiophene-2-carbonyl)-1,2,3,4-tetrahydroquinolin-7-yl)thiophene-2-sulfonamide (CAS 946220-66-2)
- trans-(15S)-Latanoprost (CAS 1235141-39-5)
- 1-(5-((4,5-Diphenyl-1H-imidazol-2-yl)sulfinyl)pentyl)-3,5-dimethyl-1H-pyrazole (CAS 136609-53-5)
- Cefazolin Impurity 59 (CAS CATO-C4X-157759)
- Cyclophosphamide Impurity 14 (CAS CATO-C4X-230614)
- Semaglutide Impurity 183 (CAS 159541-28-3)
- 4-bromo-3-methyl-thieno[2,3-c]pyridin-7-ol (CAS 2306271-99-6)
- 1,2,3-Trimethoxy-4-nitrobenzene (CAS 102872-41-3)
- (S)-4-Methyl-2-(quinazolin-4-ylamino)pentanoic acid (CAS 55040-14-7)
- 2-(3-(Chloromethyl)phenyl)thiazole (CAS 906352-60-1)
- Butyrylcholine (iodide) (CAS 2494-56-6)
- trans-3-Aminocyclopentane-1-carboxylic acid hydrochloride (CAS 1392803-15-4)
- Pancreatic Polypeptide (human) trifluoroacetate salt (CAS 75976-10-2)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com