2-Hydroxy-6-methylisonicotinic Acid CAS 86454-13-9
| CAS No. | 86454-13-9 |
| Molecular Formula | C7H7NO3 |
| Molecular Weight | 153.14 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-Hydroxy-6-methylisonicotinic Acid.
2-Hydroxy-6-methylisonicotinic Acid (CAS 86454-13-9) is a high-purity analytical reference standard with the molecular formula C7H7NO3 and a molecular weight of 153.14 g/mol.
The molecular framework of 2-Hydroxy-6-methylisonicotinic Acid (C7H7NO3) is characterized by an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2-Hydroxy-6-methylisonicotinic Acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H7NO3 |
| Molecular Weight | 153.14 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1981 |
| Nitrogen Atoms | 1 |
Related Hydroxy Standards
- 2-(2-Hydroxy-3-pyridyl)acetic Acid (CAS 100960-03-0)
- 6-Hydroxy-3-methylpyridine-2-carboxylic acid (CAS 115185-81-4)
- 5-Hydroxy-3-methylpicolinic acid (CAS 1211542-19-6)
- 5-Hydroxy-6-methylpicolinic acid (CAS 121447-41-4)
- 3-Hydroxy-1,5-pentanedioic-2,2,3,4,4-d5 Acid (CAS 1219805-72-7)
- 2-Hydroxy-5-methylpyridine-4-carboxylic acid (CAS 1227513-73-6)
- 3-Hydroxy-4-methylpyridine-2-carboxylic acid (CAS 1256788-22-3)
- 4-Hydroxy-5-methoxynicotinaldehyde (CAS 1256809-10-5)
Recommended Standards
- 2-Hydroxy-5-methylnicotinic Acid (CAS 38076-77-6)
- 2-Hydroxy-6-methylpyrimidine-4-carboxamide (CAS 88394-12-1)
- 2-Hydroxy-4-methylnicotinic Acid (CAS 38076-81-2)
- 2-Hydroxyisonicotinohydrazide (CAS 98140-91-1)
- L-759,656 (CAS 174627-56-6)
- 1,4-benzenediacetyl dichloride (CAS 21062-19-1)
- 2-(Cyclopropyl((1-methylpiperidin-4-yl)methyl)amino)ethanol (CAS 1353976-61-0)
- Sec-Pentylbenzene (CAS 2719-52-0)
- 4-(2-(4-Bromophenyl)-2H-1,2,3-triazol-4-yl)but-3-en-2-one (CAS 121650-19-9)
- N-(1-(pyridin-4-yl)ethyl)tetrahydro-2H-thiopyran-4-amine (CAS 1153144-95-6)
- 4-Hydrazinyl-5-(4-methylphenyl)thieno[2,3-d]pyrimidine (CAS 374611-25-3)
- Tert-Butyl 3-(5-Acetamido-4-Bromoisothiazol-3-Yl)Pyrrolidine-1-Carboxylate (CAS 2007917-59-9)
- 2-(Pyridin-3-yl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazole (CAS 408498-43-1)
- Semaglutide Impurity 8 (CAS CATO-C4X-22268)
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