Ethyl 5-(difluoromethoxy)picolinate CAS 864757-80-2
| CAS No. | 864757-80-2 |
| Molecular Formula | C9H9F2NO3 |
| Molecular Weight | 217.17 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 217.17 g/mol gives Ethyl 5-(difluoromethoxy)picolinate distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies Ethyl 5-(difluoromethoxy)picolinate (CAS 864757-80-2), a certified reference material (molecular formula C9H9F2NO3, MW 217.17 g/mol) for analytical method development and quality control.
Ethyl 5-(difluoromethoxy)picolinate (C9H9F2NO3) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures Ethyl 5-(difluoromethoxy)picolinate under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C9H9F2NO3 |
| Molecular Weight | 217.17 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Ethyl Standards
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- 4-(Difluoromethoxy)-3-methoxybenzamide (CAS 446267-55-6)
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Recommended Standards
- Ethyl 2-(difluoromethyl)-6-hydroxynicotinate (CAS 919354-84-0)
- Ethyl 6-(difluoromethoxy)nicotinate (CAS 2385754-58-3)
- Methyl 4-amino-2,5-difluoro-3-methoxybenzoate (CAS 2569010-43-9)
- Methyl 5-(difluoromethyl)-6-(hydroxymethyl)nicotinate (CAS 2057426-15-8)
- 2-(Difluoromethyl)-3-fluorophenol (CAS 1214333-85-3)
- 5-Ethyl-2-thioxoimidazolidin-4-one (CAS 83178-71-6)
- 5-Amino-2-(hydroxymethyl)pyridine (CAS 873651-92-4)
- 17-alfa,20-alfa-Dihydroxy Progesterone-d5 (CAS 652-69-7)
- (1S)-2,2',3,3'-Tetrahydro-4,4'-diiodo-1,1'-spirobi[1H-indene]-7,7'-diol (CAS 833455-22-4)
- 4-Bromo-2,6-dimethylquinoline (CAS 123637-45-6)
- 5-Chloro-6-methyl-1H-indole-3-carbaldehyde (CAS 1935459-78-1)
- (R)-tert-Butyl 6-bromo-7-methyl-3,4-dihydro-1H-spiro[[1,8]naphthyridine-2,3'-pyrrolidine]-1'-carboxylate (CAS 2755893-19-5)
- Ethyl 5-isopropoxy-2-methyl-4-(2-(trifluoromethyl)phenyl)-1,4-dihydro-1,6-naphthyridine-3-carboxylate (CAS 103183-79-5)
- Semaglutide impurity 91 (CAS CATO-C4X-222691)
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