1,2-Difluoro-3-(methoxymethyl)benzene CAS 865664-08-0
| CAS No. | 865664-08-0 |
| Molecular Formula | C8H8F2O |
| Molecular Weight | 158.15 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 158.15 g/mol gives 1,2-Difluoro-3-(methoxymethyl)benzene distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
1,2-Difluoro-3-(methoxymethyl)benzene (CAS 865664-08-0), molecular formula C8H8F2O and molecular weight 158.15 g/mol, is a CATO reference standard with documented purity and traceability.
Structurally, 1,2-Difluoro-3-(methoxymethyl)benzene (C8H8F2O) contains a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 4.0, corresponding to approximately 4 ring(s) or double-bond equivalent(s). With a molecular weight of 158.15 g/mol, it falls into the medium-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H8F2O |
| Molecular Weight | 158.15 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
Related Difluoro Standards
- 1,3-Difluoro-2-(methoxymethyl)benzene (CAS 110213-71-3)
- (1s)-2,2-Difluoro-1-phenylethan-1-ol (CAS 123986-75-4)
- 5,6-Difluoro-N1-methylbenzene-1,2-diamine (CAS 1248508-73-7)
- 3,5-Difluoro-4-methylanisole (CAS 1261478-94-7)
- 1,4-Difluoro-2-methoxy-5-methylbenzene (CAS 1261760-78-4)
- 2,2-Difluoro-2-phenylethanol (CAS 129973-51-9)
- (4,5-Difluoro-2-methylphenyl)methanol (CAS 1378624-91-9)
- (3,5-Difluoro-2-methylphenyl)methanol (CAS 1378666-27-3)
Recommended Standards
- 1,2-Di(furan-2-yl)ethyne (CAS 65406-81-7)
- 1,2-Difluoro-4-methoxy-5-methyl-benzene (CAS 933674-84-1)
- 1-(hydroxymethyl)-2-oxabicyclo[2.1.1]hexane-4-carboxylic acid (CAS 2416234-08-5)
- 1,2-Dimethylcyclopropane-1,2-dicarboxylic acid (CAS 89898-46-4)
- Ethyl 2-[(chloroacetyl)amino]-6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate (CAS 1221750-39-5)
- 4-Bromo-2-(bromomethyl)-3-(cyclopropylmethyl)-5-isopropyl-6-methoxypyridine (CAS 1205515-18-9)
- 6-(Propan-2-yloxy)-1h-indole-2-carboxylic acid (CAS 881041-46-9)
- 2-Methyldodec-1-ene (CAS 16435-49-7)
- Lisadimate (CAS 136-44-7)
- N-(3-Cyanothiophen-2-yl)-4-(ethylthio)benzamide (CAS 898446-66-7)
- 3-{2-ethyl-4-methyl-6-oxo-2h,6h,7h-pyrazolo[3,4-b]pyridin-7-yl}propanoic acid (CAS 1018163-76-2)
- 5-Aminolevulinic acid methyl ester hydrochloride (CAS 79416-27-6)
- 2-(Chloromethyl)-6-(difluoromethyl)-4-hydroxy-3-nitropyridine (CAS 1805066-06-1)
- Pancreatic Polypeptide (bovine) (CAS 179986-89-1)
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