2-(3-(2-(1-Bromoethyl)-4-oxoquinazolin-3(4H)-yl)propyl)isoindoline-1,3-dione CAS 866010-33-5
| CAS No. | 866010-33-5 |
| Molecular Formula | C21H18BrN3O3 |
| Molecular Weight | 440.29 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 2-(3-(2-(1-Bromoethyl)-4-oxoquinazolin-3(4H)-yl)propyl)isoindoline-1,3-dione is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, bromine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
2-(3-(2-(1-Bromoethyl)-4-oxoquinazolin-3(4H)-yl)propyl)isoindoline-1,3-dione (CAS 866010-33-5) is a high-purity analytical reference standard with the molecular formula C21H18BrN3O3 and a molecular weight of 440.29 g/mol.
The molecular framework of 2-(3-(2-(1-Bromoethyl)-4-oxoquinazolin-3(4H)-yl)propyl)isoindoline-1,3-dione (C21H18BrN3O3) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H18BrN3O3 |
| Molecular Weight | 440.29 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 3 |
Related Bromoethyl Standards
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- 2-[(2-Bromoethyl)sulfanyl]propane (CAS 5755-62-4)
- 11-(2-Bromoethyl)tricosane (CAS 1661914-65-3)
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Recommended Standards
- Alectinib Impurity 6 (CAS 1256584-80-1)
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- Methyl 4-[4,6-bis(2,2,2-trifluoroethoxy)pyrimidin-2-yl)methoxyl]benzoate (CAS 886762-33-0)
- 5-(Allyloxy)-3,4-dihydroisoquinolin-1(2h)-one (CAS 1105190-14-4)
- 5-(Trifluoromethyl)quinolin-4(1H)-one (CAS 1261845-42-4)
- Methyl 2-(3-chloro-5-fluorophenyl)benzoate (CAS 1820640-97-8)
- 4'-((4-Bromo-1H-pyrazol-1-yl)methyl)-[1,1'-biphenyl]-2-carbonitrile (CAS 850349-04-1)
- 1'-Ethyl-1'H-spiro[piperidine-4,2'-quinazolin]-4'(3'H)-one (CAS 1325304-82-2)
- 2-(3-(Tetrahydrofuran-2-yl)allylidene)hydrazinecarboxamide (CAS 194477-90-2)
- methoxy(oxan-4-ylmethyl)amine (CAS 1438858-65-1)
- 3-Methoxy-6-methylpyridazine (CAS 17644-83-6)
- 1-(2-Chloroethyl)-4-isobutylpiperazine dihydrochloride (CAS 34581-17-4)
- Peptide Impurity 28 (CAS 1350456-64-2)
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