1-Isobutyl-4,6-dimethyl-3-(o-tolylsulfonyl)pyridin-2(1H)-one CAS 866051-53-8
| CAS No. | 866051-53-8 |
| Molecular Formula | C18H23NO3S |
| Molecular Weight | 333.45 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
1-Isobutyl-4,6-dimethyl-3-(o-tolylsulfonyl)pyridin-2(1H)-one (CAS 866051-53-8) is a high-purity analytical reference standard with the molecular formula C18H23NO3S and a molecular weight of 333.45 g/mol.
The molecular framework of 1-Isobutyl-4,6-dimethyl-3-(o-tolylsulfonyl)pyridin-2(1H)-one (C18H23NO3S) is characterized by a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 1-Isobutyl-4,6-dimethyl-3-(o-tolylsulfonyl)pyridin-2(1H)-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H23NO3S |
| Molecular Weight | 333.45 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
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Recommended Standards
- 1-Butyl-4,6-dimethyl-3-(o-tolylsulfonyl)pyridin-2(1H)-one (CAS 866051-52-7)
- 2-(((2-(Piperazin-1-yl)ethyl)amino)methylene)-5-(thiophen-2-yl)cyclohexane-1,3-dione (CAS 432519-44-3)
- 1-(4-(4-Ethoxybenzo[d]thiazol-2-yl)piperazin-1-yl)butan-1-one (CAS 897478-58-9)
- 2-(4-tert-Butylphenoxy)-3-methanesulfonyl-4,6-dimethylpyridine (CAS 341967-34-8)
- 4-methoxy-1H-pyrazolo[3,4-d]pyrimidin-6-amine (CAS 100644-67-5)
- zinc titanate (CAS 12036-43-0)
- 2-((2-Cyanophenyl)sulfonyl)-N-isopropylbenzamide (CAS 477885-85-1)
- 6-Amino-5-hydroxynaphthalene-1-sulfonic acid (CAS 573-07-9)
- 1,1'-[(Methylimino)bis[2,1-ethanediyloxy(3,5-dimethoxy-4,1-phenylene)[(2E)-1-oxo-2-propene-3,1-diyl] (CAS 1415153-57-9)
- 2-(2-Fluorophenyl)-N-methoxy-N-methylacetamide (CAS 946402-23-9)
- 2-Hydroxy-8,9-dimethoxy-6H-isoindolo[2,1-a]indol-6-one (CAS 858942-71-9)
- 2-(tert-Butoxy)-5-(methylamino)phenol (CAS 1243311-78-5)
- 2-(1-Methyl-1H-pyrazol-3-yl)-6-(trifluoromethyl)pyridine (CAS 2173534-78-4)
- D-Asp9-Tirzepatide (CAS CATO-CPTD788923)
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