N-[2-(4-Methylpiperazin-1-yl)-5-(trifluoromethyl)phenyl]furan-2-carboxamide CAS 866134-08-9
| CAS No. | 866134-08-9 |
| Molecular Formula | C17H18F3N3O2 |
| Molecular Weight | 353.34 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including N-[2-(4-Methylpiperazin-1-yl)-5-(trifluoromethyl)phenyl]furan-2-carboxamide.
CATO supplies N-[2-(4-Methylpiperazin-1-yl)-5-(trifluoromethyl)phenyl]furan-2-carboxamide (CAS 866134-08-9), a certified reference material (molecular formula C17H18F3N3O2, MW 353.34 g/mol) for analytical method development and quality control.
Structurally, N-[2-(4-Methylpiperazin-1-yl)-5-(trifluoromethyl)phenyl]furan-2-carboxamide (C17H18F3N3O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 9.0, corresponding to approximately 9 ring(s) or double-bond equivalent(s). With a molecular weight of 353.34 g/mol, it falls into the moderately-high-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C17H18F3N3O2 |
| Molecular Weight | 353.34 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related N Standards
- 4-(4-Methylpiperazin-1-yl)-2-(naphthalen-2-yl)quinoline (CAS 181775-85-9)
- 3-(4-Benzyl-3-methylpiperazin-1-yl)propan-1-ol (CAS 6320-23-6)
- 4-(4-(4-Methylpiperazin-1-yl)-6-(thiophen-2-yl)pyrimidin-2-yl)aniline (CAS 832076-05-8)
- (4-Methylpiperazin-1-yl)(1-(phenylsulfonyl)piperidin-4-yl)methanone (CAS 799257-53-7)
- 3-(4-Benzyl-1-methylpiperazin-2-yl)-[1,2,4]triazolo[4,3-a]pyridine-6-carboxylic acid (CAS 1422069-61-1)
- 4-{[4-Methyl-2-(4-methylpiperazin-1-yl)quinolin-6-yl]amino}-4-oxobutanoic acid (CAS 1119449-97-6)
- 4-(4-Methylpiperazin-1-yl)-6-phenyl-2-(pyridin-2-yl)pyrimidine-5-carbonitrile (CAS 320418-22-2)
- 3-(4-Methylpiperazin-1-yl)-1-(4-(piperidin-1-yl)phenyl)pyrrolidine-2,5-dione (CAS 301313-30-4)
Recommended Standards
- N',3-dimethyl-N'-(3-phenyl-6-(trifluoromethyl)-1,2,4-triazin-5-yl)butanehydrazide (CAS 672951-03-0)
- N'-methyl-N'-(3-phenyl-6-(trifluoromethyl)-1,2,4-triazin-5-yl)pentanehydrazide (CAS 672951-07-4)
- N-(Trimethylsilyl)bis(trifluoromethanesulfonyl)imide (CAS 82113-66-4)
- N'-methyl-N'-(3-phenyl-6-(trifluoromethyl)-1,2,4-triazin-5-yl)pivalohydrazide (CAS 672951-04-1)
- N-((1-Ethylpyrrolidin-2-yl)methyl)-2,3-dimethoxy-5-sulfamoylbenzamide (CAS 80623-13-8)
- (17α)-7-Cyano-17-hydroxy-3-oxo-pregna-4,9(11)-diene-21-carboxylic acid γ-Lactone (CAS 1197900-95-0)
- methyl 1,3-difluorocyclobutanecarboxylate (CAS 2231674-47-6)
- 5-(Hydroxymethyl)-N,N-dimethylisoxazole-3-carboxamide (CAS 1638535-29-1)
- 1-(Prop-2-yn-1-yl)-1,2-dihydropyridin-2-one (CAS 36281-70-6)
- 1-Allyl-3,5-dichloro-6-phenylpyrazin-2(1H)-one (CAS 1269535-19-4)
- 3-Hydroxypyrrolidine-1-carboximidamide sulfate (CAS 1056471-60-3)
- 1,4-Benzodioxane-5-carboxylic Acid (CAS 4442-53-9)
- 1-(2,6-Dichlorobenzyl)-1H-pyrazol-4-ol (CAS 1593419-05-6)
- 3X Flag Peptide trifluoroacetate salt (CAS 402750-12-3)
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