1-(4-Methylbenzyl)-8-(trifluoromethyl)-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-one CAS 866149-49-7
| CAS No. | 866149-49-7 |
| Molecular Formula | C18H17F3N2O |
| Molecular Weight | 334.34 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), 1-(4-Methylbenzyl)-8-(trifluoromethyl)-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
1-(4-Methylbenzyl)-8-(trifluoromethyl)-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-one (CAS 866149-49-7), molecular formula C18H17F3N2O and molecular weight 334.34 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 1-(4-Methylbenzyl)-8-(trifluoromethyl)-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-one (C18H17F3N2O) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C18H17F3N2O |
| Molecular Weight | 334.34 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Methylbenzyl Standards
- N-(2-Methylbenzyl)-4-(2-phenoxyethoxy)aniline (CAS 1040690-82-1)
- N-(4-Methylbenzyl)-4-(2-phenoxyethoxy)aniline (CAS 1040690-97-8)
- 2-((4-Methylbenzyl)thio)-6-oxo-4-phenyl-1,6-dihydropyrimidine-5-carbonitrile (CAS 860649-61-2)
- 6-((2-Methylbenzyl)thio)-3-(pyridin-2-yl)-[1,2,4]triazolo[4,3-b]pyridazine (CAS 868967-96-8)
- 6-((2-Methylbenzyl)thio)-3-(pyridin-3-yl)-[1,2,4]triazolo[4,3-b]pyridazine (CAS 868969-11-3)
- 6-((2-Methylbenzyl)thio)-3-(pyridin-4-yl)-[1,2,4]triazolo[4,3-b]pyridazine (CAS 868970-19-8)
- 6-((3-Methylbenzyl)thio)-3-(pyridin-4-yl)-[1,2,4]triazolo[4,3-b]pyridazine (CAS 868970-22-3)
- 3-Methylbenzyl N,N'-diphenylcarbamimidothioate (CAS 817172-39-7)
Recommended Standards
- (5E)-3-(4-Fluorophenyl)-5-{[(4-fluorophenyl)amino]methylidene}-4-oxo-1,3-thiazolidin-1-ium-1-olate (CAS 338753-14-3)
- 1-[(4-Fluorophenyl)methyl]-6-(4-methoxyphenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile (CAS 252060-11-0)
- 5-Bromo-6-chloro-2-iodopyridin-3-ol (CAS 188057-55-8)
- 2-((5-Amino-1,3,4-thiadiazol-2-yl)thio)-N-(4-(trifluoromethyl)phenyl)acetamide (CAS 763125-98-0)
- Carbophenothion-sulfone (CAS 16662-85-4)
- (4S,4'S)-2,2'-(Cycloheptane-1,1-diyl)bis(4-phenyl-4,5-dihydrooxazole) (CAS 2185014-90-6)
- Ecabet sodium (CAS 86408-72-2)
- 951400-19-4 2-{2,5-Bis[(~2~H_3_)methyloxy]-4-(propylsulfanyl)phenyl}ethan-1-amine--hydrogen chloride (1/1) DTXSID60582559 (CAS 951400-19-4)
- tert-Butyl (1R,5S)-3,6-Diazabicyclo[3.2.1]octane-6-carboxylate (CAS 1058737-47-5)
- N-((4-(2,5-Dioxopyrrolidin-1-yl)phenyl)sulfonyl)acetamide (CAS 40266-13-5)
- (2S,3S)-2,3-Difluoro-3-Methylcyclohexanone (CAS 172969-00-5)
- 3-(3-Fluorophenyl)-4-methyl-1h-pyrazol-5-amine (CAS 2156911-03-2)
- 1h-1,3-Benzodiazol-5-yl(phenyl)methanamine dihydrochloride (CAS 1354951-93-1)
- [D-Phe22]Semaglutide (CAS CATO-C4X-2226222)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com