Methyl 3-[N-(2-fluorobenzoyl)2-fluorobenzamido]-4-methylthiophene-2-carboxylate CAS 866150-48-3

Purity 97%+In StockPharmaceutical Standards
CAS No.866150-48-3
Molecular FormulaC21H15F2NO4S
Molecular Weight415.41 g/mol
CategoryPharmaceutical Standards / API Standards
AvailabilityIn Stock

Chemical Structure

Methyl 3-[N-(2-fluorobenzoyl)2-fluorobenzamido]-4-methylthiophene-2-carboxylate CAS 866150-48-3 chemical structure

Description

The occurrence of Methyl 3-[N-(2-fluorobenzoyl)2-fluorobenzamido]-4-methylthiophene-2-carboxylate is closely related to a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.

Methyl 3-[N-(2-fluorobenzoyl)2-fluorobenzamido]-4-methylthiophene-2-carboxylate (CAS 866150-48-3), molecular formula C21H15F2NO4S and molecular weight 415.41 g/mol, is a CATO reference standard with documented purity and traceability.

The molecular framework of Methyl 3-[N-(2-fluorobenzoyl)2-fluorobenzamido]-4-methylthiophene-2-carboxylate (C21H15F2NO4S) is characterized by a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

As a certified reference material (CRM), Methyl 3-[N-(2-fluorobenzoyl)2-fluorobenzamido]-4-methylthiophene-2-carboxylate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

Molecular FormulaC21H15F2NO4S
Molecular Weight415.41 g/mol
Purity97%+
StorageStore at room temperature, protect from light, keep sealed and dry
Solubility (reference)Soluble in methanol, acetonitrile, DMSO, water (slightly soluble)
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions
Degree of Unsaturation (DBE)14.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)1987
Halogen ContentF-containing
Nitrogen Atoms1
Sulfur Atoms1

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