6-Chloro-N4-(3,5-difluoro-4-((3-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy)phenyl)pyrimidine-2,4-diamine CAS 867017-68-3
| CAS No. | 867017-68-3 |
| Molecular Formula | C18H13ClF2N6O |
| Molecular Weight | 402.79 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 6-Chloro-N4-(3,5-difluoro-4-((3-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy)phenyl)pyrimidine-2,4-diamine.
6-Chloro-N4-(3,5-difluoro-4-((3-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy)phenyl)pyrimidine-2,4-diamine (CAS 867017-68-3), molecular formula C18H13ClF2N6O and molecular weight 402.79 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 6-Chloro-N4-(3,5-difluoro-4-((3-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy)phenyl)pyrimidine-2,4-diamine (C18H13ClF2N6O) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 6-Chloro-N4-(3,5-difluoro-4-((3-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy)phenyl)pyrimidine-2,4-diamine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H13ClF2N6O |
| Molecular Weight | 402.79 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 6 |
Related Chloro Standards
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- 3-Nitro-4-(trifluoromethoxy)-5-(trifluoromethyl)pyridine-2-sulfonyl chloride (CAS 1806758-72-4)
- 2-(4-Ethyltetrahydro-2H-pyran-4-yl)acetic acid (CAS 1439896-77-1)
- Ammoxetine Impurity 25 (CAS CATO-C4X-224425)
- 5-Chloro-1h-indol-3-yl acetate (CAS 114306-00-2)
- (1S,2S,5R)-methyl 3-((S)-2-amino-3,3-dimethylbutanoyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxylate (hydrochloride) (CAS 847644-96-6)
- 7-Methoxy-2-(methylthio)benzo[d]thiazole (CAS 2942-19-0)
- Ramipril Impurity 2 Hydrochloride (CAS 138877-09-5)
- 2-Chloro-1-methyl-4-(trichloromethoxy)benzene (CAS 1404194-40-6)
- Semaglutide impurity 45 (CAS CATO-C4X-222645)
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