Ethyl 5-chloro-2-methylnicotinate CAS 868636-76-4
| CAS No. | 868636-76-4 |
| Molecular Formula | C9H10ClNO2 |
| Molecular Weight | 199.63 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Ethyl 5-chloro-2-methylnicotinate is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Ethyl 5-chloro-2-methylnicotinate (CAS 868636-76-4) is a high-purity analytical reference standard with the molecular formula C9H10ClNO2 and a molecular weight of 199.63 g/mol.
Ethyl 5-chloro-2-methylnicotinate (C9H10ClNO2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), Ethyl 5-chloro-2-methylnicotinate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H10ClNO2 |
| Molecular Weight | 199.63 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Ethyl Standards
- 4-Chloro-1-ethyl-6-methyl-2-oxo-1,2-dihydropyridine-3-carbaldehyde (CAS 1018525-23-9)
- Ethyl 6-chloro-4-methylpyridine-2-carboxylate (CAS 1122090-50-9)
- 3-Chloro-1-(cyclopropylmethyl)-4-hydroxypyridin-2(1H)-one (CAS 1128149-77-8)
- Ethyl 4-chloro-6-methylnicotinate (CAS 1142188-94-0)
- 2-Chloro-5-((tetrahydrofuran-3-yl)oxy)pyridine (CAS 1204483-97-5)
- Ethyl 3-chloro-2-methylisonicotinate (CAS 1227603-49-7)
- 3-Chloro-5-hydroxy-N,N-dimethylbenzamide (CAS 1243279-42-6)
- 2-CHloro-4-hydroxy-n,n-dimethylbenzamide (CAS 1243310-69-1)
Recommended Standards
- Ethyl 5-amino-2-chlorobenzoate (CAS 64401-55-4)
- ethyl 6-(chloromethyl)picolinate (CAS 49668-99-7)
- Ethyl 4-chloro-6-methylpicolinate (CAS 315494-03-2)
- ethyl 6-chloro-2-methylpyridine-3-carboxylate (CAS 31163-12-9)
- 8-(Dimethoxymethyl)-3,4-dihydro-2H-pyrano[3,2-b]pyridine (CAS 1346447-02-6)
- H-Pro-NHEt · HCl (CAS 58107-62-3)
- tert-Butyl (3S,4S)-4-(((R)-tert-butylsulfinyl)amino)-3-methyl-2-oxa-8-azaspiro[4.5]decane-8-carboxylate (CAS 1801766-78-8)
- Tert-butyl (s)-(1-(pyrimidin-2-yl)pyrrolidin-3-yl)carbamate (CAS 1421019-15-9)
- 2-Chloro-6-iodo-3-methoxybenzaldehyde (CAS 2383017-43-2)
- 1-(4-Bromo-3-chlorophenyl)-4-methylpiperazine (CAS 1426958-37-3)
- 5-Bromo-2-(isopropylthio)pyridine (CAS 98626-93-8)
- 2-((Bis(pyridin-3-ylmethyl)amino)methyl)-3-hydroxy-6-(hydroxymethyl)-4H-pyran-4-one (CAS 866019-65-0)
- 2-(benzyloxy)-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile (CAS 1448894-65-2)
- Semaglutide impurity 268 (CAS CATO-C4X-2226268)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com