Methyl 2,2-difluorobutanoate CAS 86966-96-3
| CAS No. | 86966-96-3 |
| Molecular Formula | C5H8F2O2 |
| Molecular Weight | 138.11 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Methyl 2,2-difluorobutanoate (CAS 86966-96-3) is a high-purity analytical reference standard with the molecular formula C5H8F2O2 and a molecular weight of 138.11 g/mol.
The molecular framework of Methyl 2,2-difluorobutanoate (C5H8F2O2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), Methyl 2,2-difluorobutanoate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C5H8F2O2 |
| Molecular Weight | 138.11 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 1.0 |
| CAS Registry Year (est.) | 1981 |
| Halogen Content | F-containing |
Related Methyl Standards
- methyl 4,4-difluorobutanoate (CAS 1866071-82-0)
- Ethyl 4,4-difluorobutanoate (CAS 1240725-43-2)
- Ethyl 2,2-difluorobutanoate (CAS 2368-92-5)
- Ethyl 3,3-difluorobutanoate 3,3-Difluorobutyric acid ethyl ester 2368-93-6 (CAS 2368-93-6)
- Butyl 2,2-difluorobutanoate (CAS 1000339-45-6)
- Sodium 2,2-difluorobutanoate (CAS 1346521-51-4)
Recommended Standards
- Ethyl 3,3-difluoropropanoate (CAS 28781-80-8)
- 4-Hydroxypicolinamide (CAS 100047-35-6)
- Ethyl 2,2-Difluoropropionate (CAS 28781-85-3)
- 4-Aminopyridine-2-carboxylic Acid (CAS 100047-36-7)
- trans-2-Methyl-3-Phenyl-Aziridine (CAS 20993-60-6)
- 6-(2,3,4-Trimethoxyphenyl)pyridazin-3-ol (CAS 1105194-15-7)
- 4-Methanesulfonylbutanoic acid (CAS 148928-08-9)
- (4-(Bromomethyl)-5-(difluoromethyl)-6-iodopyridin-2-yl)methanol (CAS 1807140-33-5)
- 3-((4-Amino-1,3-dimethyl-1h-pyrazol-5-yl)oxy)propan-1-ol (CAS 1153370-07-0)
- 5-Amino-4-(1h-benzo[d]imidazol-2-yl)-1-(2-morpholinoethyl)-1,2-dihydro-3h-pyrrol-3-one (CAS 459213-95-7)
- N,N-Dibenzyl-2-chloroacetamide (CAS 2567-51-3)
- 2-Cyano-3-fluorobenzeneboronic acid pinacol ester, 97% (CAS 765916-91-4)
- Tert-butyl 4-oxo-8-oxa-2-azaspiro[4.5]Decane-2-carboxylate (CAS 2126162-41-0)
- Semaglutide impurity 88 (CAS CATO-C4X-222688)
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