4-Cyclopropyl-6-(difluoromethyl)-2-(piperazin-1-yl)pyrimidine CAS 869952-76-1
| CAS No. | 869952-76-1 |
| Molecular Formula | C12H16F2N4 |
| Molecular Weight | 254.28 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
4-Cyclopropyl-6-(difluoromethyl)-2-(piperazin-1-yl)pyrimidine (CAS 869952-76-1) is a high-purity analytical reference standard with the molecular formula C12H16F2N4 and a molecular weight of 254.28 g/mol.
4-Cyclopropyl-6-(difluoromethyl)-2-(piperazin-1-yl)pyrimidine (C12H16F2N4) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), 4-Cyclopropyl-6-(difluoromethyl)-2-(piperazin-1-yl)pyrimidine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H16F2N4 |
| Molecular Weight | 254.28 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
Related Cyclopropyl Standards
- 4-Cyclopropyl-2-(p-tolyl)pyrimidine-5-carboxylic acid (CAS 1284373-37-0)
- n'-Cyclopropyl-n-(4-fluorophenyl)benzenecarboximidamide (CAS 872019-57-3)
- n-Cyclopropyl-n-(2,4-dimethylthiazole-5-carbonyl)glycine (CAS 1178839-05-8)
- Cyclopropyl 4-methoxydiphenylcarbinol (CAS 62587-03-5)
- [2-(Acetyl-cyclopropyl-amino)-cyclohexylamino]-acetic acid (CAS 1353985-87-1)
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- N-cyclopropyl-5-bromo-3-methylpyridine-2-carboxamide (CAS 2230481-36-2)
- 1-Cyclopropyl-N-[(4-phenoxyphenyl)methyl]methanamine (CAS 169943-53-7)
Recommended Standards
- 4-Amino-N-propyl-1,8-naphthalimide (CAS 94860-68-1)
- 4'-Formyl-biphenyl-4-carboxylic acid ethyl ester (CAS 70917-02-1)
- 4-Amino-2-methyl-6-(6-methylbenzo[d]oxazol-2-yl)phenol (CAS 874592-15-1)
- 4H-Cyclopenta[def]chrysen-4-one (CAS 86853-91-0)
- Methyl 2-(cyanomethyl)-3-nitrobenzoate (CAS 90771-65-6)
- [2-(4-Methyl-1,3-thiazol-2-yl)ethyl]amine dihydrochloride (CAS 1134723-32-2)
- Isopropyl (3-chloro-4-fluorophenyl)alaninate (CAS 52756-24-8)
- 5-(4-Methoxy-2,3,6-trimethylphenyl)-3-methyl-2,4-pentadien-1-ol (CAS 167637-42-5)
- Tert-Butylhydrazine Hydrochloride (CAS 7400-27-3)
- 2-Bromo-6-methylpyridin-4-amine (CAS 79055-59-7)
- 1'-(Pyridazine-4-carbonyl)spiro[indoline-3,4'-piperidin]-2-one (CAS 1658415-29-2)
- 6-Bromo-5-cyclopropoxy-N-methylpicolinamide (CAS 1243410-42-5)
- Ovalicin (CAS 19683-98-8)
- Semaglutide impurity 60 (CAS CATO-C4X-222660)
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