1-(5-Chloro-2-pyridyl)piperazine CAS 87394-65-8
| CAS No. | 87394-65-8 |
| Molecular Formula | C9H12ClN3 |
| Molecular Weight | 197.66 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 1-(5-Chloro-2-pyridyl)piperazine (C9H12ClN3) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
1-(5-Chloro-2-pyridyl)piperazine (CAS 87394-65-8) is a high-purity analytical reference standard with the molecular formula C9H12ClN3 and a molecular weight of 197.66 g/mol.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H12ClN3 |
| Molecular Weight | 197.66 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1981 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Chloro Standards
- 2-Chloro-4-(piperidin-4-yl)pyrimidine (CAS 1001754-79-5)
- 3-(4-Chloro-3,5-dimethyl-1H-pyrazol-1-yl)butanenitrile (CAS 1007489-25-9)
- 2-Chloro-5-(1-piperidinyl)pyrazine (CAS 1017781-70-2)
- 2-Chloro-5-[(cyclopropylmethoxy)methyl]pyridine (CAS 1019546-38-3)
- 5-Chloro-2-(cyclopropylmethoxy)aniline (CAS 1021105-81-6)
- 9-Chloro-2,3,4,5-tetrahydrobenzo[b]oxepin-5-amine (CAS 1094299-22-5)
- 8-Chloro-5-methylchroman-4-amine (CAS 1094546-75-4)
- 2-Chloro-1-(4-(dimethylamino)phenyl)ethanone (CAS 110945-00-1)
Recommended Standards
- 1-(4-Chloropyridin-3-yl)piperazine (CAS 67980-90-9)
- 1-(5-Chloropyridin-3-yl)piperazine (CAS 223794-95-4)
- 1-(4-Chlorophenyl)pyrrolidin-3-ol (CAS 536742-63-9)
- 1-(6-Chloro-pyridin-2-yl)-piperazine (CAS 87394-54-5)
- (S)-tert-Butyl (3-methyl-2-oxopyrrolidin-3-yl)carbamate (CAS 261521-49-7)
- 7-(Trifluoromethyl)-2-azabicyclo[4.1.0]heptane hydrochloride (CAS 1311315-27-1)
- Methyl3-amino-4-cyano-5-methylthiophene-2-carboxylate (CAS 85092-72-4)
- 5-Methyloxazole-4-acetic Acid (CAS 1507656-31-6)
- 2-Fluoro-5-sulfobenzoic acid (CAS 881487-27-0)
- 2-Fluoro-4-methoxy-6-methylpyridine (CAS 1227511-44-5)
- 4-Methyl-2-(methylthio)-5-pyridylboronic acid (CAS 1451392-61-2)
- Ethyl 5-((p-tolylthio)methyl)isoxazole-3-carboxylate (CAS 823219-85-8)
- 3-(2-Bromophenyl)-1H-pyrazole-5-carboxylic acid (CAS 1038915-04-6)
- [D-His]-Semaglutide B (x TFA Salt) (CAS CATO-C4X-2226117)
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