2-Chloro-n-[(2,4,5-trimethoxyphenyl)methyl]acetamide CAS 873977-29-8
| CAS No. | 873977-29-8 |
| Molecular Formula | C12H16ClNO4 |
| Molecular Weight | 273.71 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-Chloro-n-[(2,4,5-trimethoxyphenyl)methyl]acetamide.
2-Chloro-n-[(2,4,5-trimethoxyphenyl)methyl]acetamide (CAS 873977-29-8), molecular formula C12H16ClNO4 and molecular weight 273.71 g/mol, is a CATO reference standard with documented purity and traceability.
Structurally, 2-Chloro-n-[(2,4,5-trimethoxyphenyl)methyl]acetamide (C12H16ClNO4) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 5.0, corresponding to approximately 5 ring(s) or double-bond equivalent(s). With a molecular weight of 273.71 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2-Chloro-n-[(2,4,5-trimethoxyphenyl)methyl]acetamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H16ClNO4 |
| Molecular Weight | 273.71 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Chloro Standards
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- 3-Chloro-5-[(4-methoxybenzyl)oxy]benzonitrile (CAS 1213790-87-4)
- 2-chloro-N-[(2,4,6-trimethoxyphenyl)methyl]acetamide (CAS 1306606-37-0)
- 8-Chloro-3-methoxy-5,6-dihydro-11H-benzo[5,6]-cyclohepta[1,2-β]pyridin-11- one (CAS 165739-70-8)
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Recommended Standards
- 2-chloro-N-(3,4,5-trimethoxybenzyl)acetamide (CAS 923153-49-5)
- 3-(4-Chlorophenyl)-3-methoxyisoindolin-1-one (CAS 730-77-8)
- 2-Chloro-3-oxo-n,3-diphenylpropanamide (CAS 27525-98-0)
- 3-Chloro-6-fluoro-N-(2-hydroxyethyl)benzo[b]thiophene-2-carboxamide (CAS 721426-21-7)
- 2-(1-Methyl-piperidin-4-ylmethoxy)-ethanol (CAS 112391-05-6)
- ethyl 2-(7-hydroxy-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetate (CAS 1206124-13-1)
- (S)-2-(2-Aminopropoxy)acetic acid hydrochloride (CAS 2641694-29-1)
- 1H-Indole-5-carbonitrile, 4-chloro-1,3-dimethyl- (CAS 2112656-22-9)
- ethyl 4-amino-1-methyl-pyrazole-3-carboxylate (CAS 1228552-85-9)
- Ethyl 6-bromo-2-oxo-2H-chromene-3-carboxylate (CAS 2199-90-8)
- (4-(Benzyl(methyl)carbamoyl)-3-fluorophenyl)boronic acid (CAS 2096336-40-0)
- Methyl 2-(4-oxo-2-sulfanyl-3,4-dihydroquinazolin-3-yl)acetate (CAS 85716-94-5)
- 2-Amino-6-bromo-3,5-dimethylbenzoic Acid (CAS 1603580-85-3)
- Semaglutide impurity 73 (CAS CATO-C4X-222673)
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