2-Amino-6-chloro-3-methylpyrimidin-4(3H)-one CAS 874-20-4

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-Amino-6-chloro-3-methylpyrimidin-4(3H)-one.

2-Amino-6-chloro-3-methylpyrimidin-4(3H)-one (CAS 874-20-4) is a high-purity analytical reference standard with the molecular formula C5H6ClN3O and a molecular weight of 159.57 g/mol.

Owing to an amide group, a hydroxyl group, an ether linkage, chlorine substitution, 2-Amino-6-chloro-3-methylpyrimidin-4(3H)-one is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 159.57 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

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