2-(2-Chloro-4,5-difluorophenyl)acetonitrile CAS 874285-22-0
| CAS No. | 874285-22-0 |
| Molecular Formula | C8H4ClF2N |
| Molecular Weight | 187.57 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2-(2-Chloro-4,5-difluorophenyl)acetonitrile (C8H4ClF2N) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
CATO supplies 2-(2-Chloro-4,5-difluorophenyl)acetonitrile (CAS 874285-22-0), a certified reference material (molecular formula C8H4ClF2N, MW 187.57 g/mol) for analytical method development and quality control.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 2-(2-Chloro-4,5-difluorophenyl)acetonitrile under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C8H4ClF2N |
| Molecular Weight | 187.57 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Chloro Standards
- 2-(4-Chloro-3,5-difluorophenyl)acetonitrile (CAS 1000540-50-0)
- 4-Chloro-5-(difluoromethyl)-2-fluorothiazole (CAS 105315-45-5)
- 2-chloro-2-(2,4-difluorophenyl)acetonitrile (CAS 1250050-25-9)
- 2-Chloro-6-(difluoromethyl)benzonitrile (CAS 1261440-44-1)
- 5-Chloro-2-(difluoromethyl)benzonitrile (CAS 1261440-49-6)
- 2-Chloro-4-(difluoromethyl)benzonitrile (CAS 1261646-33-6)
- 3-Chloro-5-(difluoromethyl)benzonitrile (CAS 1261737-15-8)
- 3-Chloro-2-(difluoromethyl)benzonitrile (CAS 1261776-59-3)
Recommended Standards
- 2-(2-Chloro-3,6-difluorophenyl)acetonitrile (CAS 261762-54-3)
- 2-(3-Chloro-2,6-difluorophenyl)acetonitrile (CAS 261762-55-4)
- 2-(4-Chloro-2,3-difluorophenyl)acetonitrile (CAS 1807214-44-3)
- 2-(4-Chlorophenyl)-2,2-difluoroacetonitrile (CAS 40626-54-8)
- 4-Cyclopropyl-1-(quinolin-4-yl)-1H-pyrrole-3-carboxylic acid (CAS 649727-28-6)
- 6-(4-Nitro-1H-pyrazol-1-yl)pyrazolo[1,5-a]pyrimidin-2(1H)-one (CAS 482573-96-6)
- Methyl 4-amino-5-bromo-2-fluorobenzoate (CAS 1427372-46-0)
- 8-methylquinoline-6-carbaldehyde (CAS 22934-43-6)
- N-(2-(pyridin-2-yl)ethyl)-7H-purin-6-amine (CAS 5786-66-3)
- 3,5-Bis(4-chlorophenyl)-4,5-dihydro-1H-pyrazole (CAS 50800-82-3)
- 92565-91-8 Propane-1,1,1,2,3,3,3-d7 DTXSID30440970 (CAS 92565-91-8)
- 421-83-0 Trifluoromethanesulfonyl chloride trifluoro-methanesulfonyl chloride trifluoromethanesulphonyl chloride trifluoromethylsulphonyl chloride (CAS 421-83-0)
- Ethyl 5-oxo-2,3,5,6-tetrahydro-1H-pyrrolizine-7-carboxylate (CAS 67800-67-3)
- Peptide Impurity (CAS CATO-CPTD788810)
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