2-Chloro-4-(trifluoromethoxy)benzonitrile CAS 874482-94-7
| CAS No. | 874482-94-7 |
| Molecular Formula | C8H3ClF3NO |
| Molecular Weight | 221.56 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
2-Chloro-4-(trifluoromethoxy)benzonitrile (CAS 874482-94-7), molecular formula C8H3ClF3NO and molecular weight 221.56 g/mol, is a CATO reference standard with documented purity and traceability.
Structurally, 2-Chloro-4-(trifluoromethoxy)benzonitrile (C8H3ClF3NO) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 6.0, corresponding to approximately 6 ring(s) or double-bond equivalent(s). With a molecular weight of 221.56 g/mol, it falls into the medium-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
CATO manufactures 2-Chloro-4-(trifluoromethoxy)benzonitrile under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C8H3ClF3NO |
| Molecular Weight | 221.56 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Chloro Standards
- 5-Chloro-2-(trifluoromethoxy)benzonitrile (CAS 1092461-25-0)
- 2-Chloro-5-(trifluoromethyl)benzoxazole (CAS 114997-91-0)
- 2-Chloro-6-(trifluoromethyl)benzo[d]oxazole (CAS 1248393-79-4)
- 2-Chloro-5-(trifluoromethoxy)benzonitrile (CAS 1261644-07-8)
- 2-Chloro-6-(trifluoromethoxy)benzonitrile (CAS 1261779-40-1)
- 4-Chloro-2-(trifluoromethoxy)benzonitrile (CAS 1261878-30-1)
- 3-Chloro-4-(trifluoromethoxy)benzonitrile (CAS 129604-26-8)
- 2-[Chloro(difluoro)methoxy]-6-fluoro-benzonitrile (CAS 1404193-92-5)
Recommended Standards
- 2-Chloro-1-isocyanato-4-(trifluoromethyl)benzene (CAS 51488-22-3)
- 3-Chloro-5-(trifluoromethoxy)benzonitrile (CAS 886503-29-3)
- 2-Chloro-7-(trifluoromethyl)benzo[d]oxazole (CAS 1804145-98-9)
- 4-Chloro-3-(trifluoromethoxy)benzonitrile (CAS 886501-50-4)
- Penfluridol Impurity 14 (CAS 106392-60-3)
- (5E)-5-[(2-Fluorophenyl)methylidene]-1,3-thiazolidine-2,4-dione (CAS 262601-89-8)
- 3-Butyl-1-methyl-3-imidazolium Dibutyl Phosphate (CAS 663199-28-8)
- 2-(1H-Imidazol-1-yl)-6-nitropyridine (CAS 1823888-02-3)
- 3,4-Dichlorobenzo[d]isoxazole (CAS 1344687-55-3)
- Carbetocin Impurity 7 (CAS CATO-C4X-19117)
- (S)-2-Methylpyrrolidine-2-carboxamide hydrochloride (CAS 1262381-66-7)
- 3,3-Dimethoxy-2-methylprop-1-ene (CAS 23230-91-3)
- 4-Cyclopropoxy-1-iodo-2-nitrobenzene (CAS 1243350-08-4)
- Insulin Degludec Impurity 3 (CAS CATO-C4X-21573)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com