5-Oxo-1-[4-(trifluoromethoxy)phenyl]pyrrolidine-3-carboxylic acid CAS 874765-55-6
| CAS No. | 874765-55-6 |
| Molecular Formula | C12H10F3NO4 |
| Molecular Weight | 289.21 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 5-Oxo-1-[4-(trifluoromethoxy)phenyl]pyrrolidine-3-carboxylic acid.
5-Oxo-1-[4-(trifluoromethoxy)phenyl]pyrrolidine-3-carboxylic acid (CAS 874765-55-6), molecular formula C12H10F3NO4 and molecular weight 289.21 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 5-Oxo-1-[4-(trifluoromethoxy)phenyl]pyrrolidine-3-carboxylic acid (C12H10F3NO4) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 5-Oxo-1-[4-(trifluoromethoxy)phenyl]pyrrolidine-3-carboxylic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H10F3NO4 |
| Molecular Weight | 289.21 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Oxo Standards
- 2-oxo-1-[3-(trifluoromethoxy)phenyl]pyrrolidine-3-carboxylic acid (CAS 1016508-24-9)
- 5-Oxo-1-(3-(trifluoromethoxy)phenyl)pyrrolidine-3-carboxylic acid (CAS 1016706-55-0)
- 5-Oxo-1-(2-(trifluoromethoxy)phenyl)pyrrolidine-3-carboxylic acid (CAS 1016757-33-7)
- 2-[4-(Trifluoromethoxy)phenyl]-1,3-thiazole-4-carboxylic acid (CAS 886368-65-6)
- 2-[4-(Trifluoromethoxy)phenyl]thiazole-5-carboxylic Acid (CAS 886370-20-3)
- 4-(4-(Trifluoromethoxy)phenyl)thiazole-2-carboxylic acid (CAS 886367-05-1)
- (2,4-Bis(trifluoromethoxy)phenyl)boronic acid (CAS 511521-83-8)
- 5-[4-(trifluoromethoxy)phenyl]thiophene-2-carboxylic acid (CAS 1039859-73-8)
Recommended Standards
- 4-Bromo-4'-butyl-1,1'-biphenyl (CAS 63619-54-5)
- ethyl 6-bromonaphthalene-2-carboxylate (CAS 86471-14-9)
- 2-bromo-1-[4-(4-methyl-1H-imidazol-1-yl)phenyl]ethan-1-one (CAS 810662-38-5)
- Methyl 1-(2-nitro-4-(trifluoromethyl)phenyl)cyclopropane-1-carboxylate (CAS 951885-67-9)
- (2-Hydroxy-6-methoxyphenyl)(phenyl)methanone (CAS 20034-63-3)
- N-cyclopropyl-2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide (CAS 1112329-70-0)
- 2-Methoxy-N-methylpyridine-3-carboxamide (CAS 1208461-39-5)
- Boc-N-Me-Phe-OH (CAS 37553-65-4)
- 3-methoxy-1-methyl-1H-pyrazole-4-carboxylic acid (CAS 113100-56-4)
- 2-Methoxy-4,5,6-trimethylpyridine-3-carboxamide (CAS 2197055-73-3)
- Methyl 6-bromo-1,2,3,4-tetrahydronaphthalene-2-carboxylate (CAS 2091528-80-0)
- 3-Fluoro-7,7-dimethyl-1,5,7,8-tetrahydro-2H-pyrano[4,3-b]pyridin-2-one (CAS 2768871-19-6)
- Methyl (2Z)-2-(benzenesulfonyl)-3-[(4-chlorophenyl)amino]prop-2-enoate (CAS 1327173-69-2)
- Des-Pro36-Tirzepatide (CAS CATO-CPTD788937)
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