5-Bromo-2-fluoro-4-methylbenzenesulfonyl chloride CAS 874801-49-7
| CAS No. | 874801-49-7 |
| Molecular Formula | C7H5BrClFO2S |
| Molecular Weight | 287.53 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies 5-Bromo-2-fluoro-4-methylbenzenesulfonyl chloride (CAS 874801-49-7), a certified reference material (molecular formula C7H5BrClFO2S, MW 287.53 g/mol) for analytical method development and quality control.
Owing to a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine/bromine substitution, an aromatic ring system, 5-Bromo-2-fluoro-4-methylbenzenesulfonyl chloride is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 287.53 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H5BrClFO2S |
| Molecular Weight | 287.53 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F/Cl/Br-containing |
| Sulfur Atoms | 1 |
Related Bromo Standards
- (2-Bromo-4-fluorophenyl)methanesulfonyl chloride (CAS 1178315-16-6)
- (4-Bromo-2-fluorophenyl)methanesulfonyl chloride (CAS 1178830-06-2)
- (3-Bromo-4-fluorophenyl)methanesulfonyl chloride (CAS 1179247-63-2)
- (5-Bromo-2-fluorophenyl)methanesulfonyl chloride (CAS 1184467-10-4)
- (2-Bromo-5-fluorophenyl)methanesulfonyl chloride (CAS 1184712-30-8)
- 4-Bromo-3-fluoro-2-methylbenzenesulfonyl chloride (CAS 1208074-74-1)
- 2-Bromo-6-fluoro-4-methylbenzene-1-sulfonyl chloride (CAS 1208076-93-0)
- 4-Bromo-5-fluoro-2-methylbenzene-1-sulfonyl chloride (CAS 1208076-97-4)
Recommended Standards
- 5-Amino-1-(2,4,6-trichlorophenyl)-1H-pyrazole-4-carbonitrile (CAS 79002-96-3)
- 5-Bromo-4-fluoro-2-methylbenzene-1-sulfonyl chloride (CAS 874804-12-3)
- 4-chloro-6-iodo-7H-pyrrolo[2,3-d]pyrimidine (CAS 876343-10-1)
- 6-chloro-3-iodo-pyrazolo[1,5-a]pyrimidine (CAS 2306264-38-8)
- 2-Chloro-N,N-dimethyl-5-nitrobenzenesulfonamide (CAS 10372-90-4)
- (R)-N-((R)-2-fluoro-1-phenylethyl)-2-methylpropane-2-sulfinamide (CAS 1428330-77-1)
- Ethyl 2,4-diethoxy-5-iodobenzoate (CAS 1131587-50-2)
- 1,2,3,4,6-Penta-O-benzoyl-b-D-galactopyranose (CAS 41545-56-6)
- 2,8-Dimethylimidazo[1,2-b]pyridazine-6-carboxylic acid hydrochloride (CAS 2344680-05-1)
- 6-Bromo-4-oxo-3,4-dihydro-2H-1-benzopyran-3-carbaldehyde (CAS 478912-35-5)
- 1-[4-(5-Amino-3-phenyl-1H-pyrazol-1-yl)piperidin-1-yl]ethan-1-one (CAS 1365968-54-2)
- 4-Chloro-5-((furan-2-ylmethyl)thio)-2-methylpyridazin-3(2H)-one (CAS 465514-01-6)
- {[(4-Chlorophenyl)methyl]sulfanyl}methanimidamide hydrobromide (CAS 90732-58-4)
- Crustacean Cardioactive Peptide (CCAP) (CAS 309247-84-5)
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