Toceranib phosphate CAS 874819-74-6
| CAS No. | 874819-74-6 |
| Molecular Formula | C22H25FN4O2 |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Toceranib phosphate (CAS 874819-74-6) is a high-purity analytical reference standard with the molecular formula C22H25FN4O2H3O4P and a molecular weight of 494.46 g/mol.
Toceranib phosphate (C22H25FN4O2H3O4P) contains a flavonoid core, an amide group, a phosphate ester group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H25FN4O2 H3O4P |
| Molecular Weight | 494.46 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
Related Toceranib Standards
Recommended Standards
- N-(4,4-difluorocyclohexylidene)hydroxylamine (CAS 2021983-28-6)
- 2-(Difluoromethyl)-4-methoxy-5-(trifluoromethyl)pyridine-3-carboxylic acid (CAS 1805151-34-1)
- Benzo[d]oxazole-2-sulfonyl chloride (CAS 1026975-53-0)
- 6-(2-Methyl-1h-imidazol-1-yl)pyridin-3-amine (CAS 430535-32-3)
- 1-(4-Iodobenzo[d]oxazol-2-yl)ethanone (CAS 1803836-74-9)
- 2-Chloro-4'-(trifluoromethyl)-[1,1'-biphenyl]-3-amine (CAS 1261747-48-1)
- 1-(3,4-Dimethylphenyl)butan-2-ol (CAS 1247747-74-5)
- 3-(4-Chlorophenyl)-1-(4-methoxyphenyl)-1H-pyrazol-5-amine (CAS 618098-06-9)
- 2,2-Dichloroethanol (CAS 598-38-9)
- D-Phe22-Tirzepatide (CAS CATO-CPTD788912)
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