Carfilzomib Impurity 39 CAS 875309-82-3
| CAS No. | 875309-82-3 |
| Molecular Formula | C33H41N3O4 |
| Molecular Weight | 543.70 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Carfilzomib Impurity 39 (CAS 875309-82-3, C33H41N3O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Carfilzomib Impurity 39 (C33H41N3O4) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C33H41N3O4 |
| Molecular Weight | 543.70 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Nitrogen Atoms | 3 |
Related Carfilzomib Standards
- Carfilzomib Impurity 83 (CAS CATO-C4X-102283)
- Carfilzomib Impurity 35 (CAS 868539-96-2)
- Carfilzomib Impurity 49 (CAS CATO-C4X-102249)
- Carfilzomib Impurity 1 (CAS 875309-92-5)
- Carfilzomib Impurity 15 (CAS CATO-C4X-102215)
- Carfilzomib Impurity 16 (CAS CATO-C4X-102216)
- Carfilzomib Impurity 17 (CAS CATO-C4X-102217)
- Carfilzomib Impurity 18 (CAS CATO-C4X-102218)
Recommended Standards
- H-Leu-Ala-Leu-Lys(Boc)-OH (CAS 149440-52-8)
- NB-851 (CAS 943925-09-5)
- (S)-4-(4,7-Bis(2-(tert-butoxy)-2-oxoethyl)-1,4,7-triazonan-1-yl)-5-(tert-butoxy)-5-oxopentanoic acid (CAS 438553-50-5)
- 1314795-11-3 273K4V0SPC Radalbuvir [INN] UNII-273K4V0SPC GS-9669 2-Thiophenecarboxylic acid, 5-(3,3-dimethyl-1-butyn-1-yl)-3-((cis-4-hydroxy-4-((((3S)-tetrahydro-3-furanyl)oxy)methyl)cyclohexyl)(((1R)-4-methyl-3-cyclohexen-1-yl)carbonyl)amino)- Radalbuvir (CAS 1314795-11-3)
- Marbofloxacin EP Impurity E HCl (CAS 2249835-04-7 (free base))
- Desloratadine Impurity 36 (CAS 1193725-75-5)
- Biapenem impurity 18 (CAS CATO-C4X-227318)
- 3-(4-Bromo-2-fluorobenzyl)-4-oxo-3,4-dihydrophthalazin-1-yl acetate (CAS 112106-75-9)
- N1-(3-Acetamidophenyl)-N2-((1-methylpiperidin-4-yl)methyl)oxalamide (CAS 952975-04-1)
- 4-Bromo-5-iso-propyl-3-(trifluoromethyl)-1H-Pyrazole (CAS 1256962-73-8)
- (1-(2-(Methylthio)pyrimidin-4-yl)piperidin-4-yl)methanol (CAS 1261233-54-8)
- tert-Butyl (3-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)carbamate (CAS 1384312-60-0)
- 4-Phenylpyrimidine (CAS 3438-48-0)
- Semaglutide Impurity 165 (CAS CATO-C4X-2226165)
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